{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:10:24Z","timestamp":1792512624427,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      To evaluate the effects of orthodontic palatal plate therapy (\n                      <jats:styled-content style=\"fixed-case\">OPPT<\/jats:styled-content>\n                      ) in the treatment of orofacial dysfunction in children with Down syndrome (\n                      <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n                      ). Indexed databases were searched. Clinical trials in\n                      <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n                      allocated to test (treatment with palatal plates) versus control group (without palatal plates\/special physiotherapy for orofacial stimulation) with follow\u2010up of any time duration and assessing mouth closure, tongue position, active and inactive muscle function as outcomes. Study designs, subject demographics, frequency and duration of palatal plate therapy, method for assessment, follow\u2010up period and outcomes were reported according to the\n                      <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content>\n                      guidelines. Eight clinical studies were included. The risk of bias was considered high in three studies and moderate in 5 studies. The number of children with\n                      <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n                      ranged between 9 and 42. The mean age of children with\n                      <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n                      at the start of the study ranged between 2\u00a0months and 12\u00a0years. The duration of palatal plate therapy ranged between 4\u00a0months and 48\u00a0months. The follow\u2010up period in all studies ranged from 12 to 58\u00a0months. All studies reported\n                      <jats:styled-content style=\"fixed-case\">OPPT<\/jats:styled-content>\n                      to be effective in improving orofacial disorders in children with\n                      <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n                      . Most of the included studies suggest that palatal plate therapy in combination with physiotherapy\/orofacial regulation therapy according to Castillo Morales\/speech and language intervention seems to be effective in improving orofacial disorders in children with\n                      <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n                      . However, the risk of bias of the included studies was high to moderate. Longitudinal trials with standardized evaluation methods, age of children at treatment initiation, treatment duration and standard orofacial outcomes are recommended.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ocr.12211","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T08:29:04Z","timestamp":1513067344000},"page":"20-26","source":"Crossref","is-referenced-by-count":29,"title":["Outcome of orthodontic palatal plate therapy for orofacial dysfunction in children with Down syndrome: A systematic review"],"prefix":"10.1111","volume":"21","author":[{"given":"F.","family":"Javed","sequence":"first","affiliation":[{"name":"Department of General Dentistry Eastman Institute for Oral Health University of Rochester  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9618-8818","authenticated-orcid":false,"given":"Z.","family":"Akram","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Department of Periodontology Ziauddin University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P.","family":"Barillas","sequence":"additional","affiliation":[{"name":"Department of General Dentistry Eastman Institute for Oral Health University of Rochester  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. V.","family":"Kellesarian","sequence":"additional","affiliation":[{"name":"Department of General Dentistry Eastman Institute for Oral Health University of Rochester  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. B.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Private Dental Practitioner  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Orofacial Pain and Temporomandibular Joint Disorders Eastman Institute for Oral Health University of Rochester  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Almas","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Sciences College of Dentistry Imam Abdulrahman Bin Faisal University  Dammam Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01358711"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.20883\/medical.e59","article-title":"The role of the orthodontist in the early simulating plate rehabilitation of children with down syndrome","volume":"83","author":"Matthews\u2010Brzozowska T","year":"2016","journal-title":"J Med Sci"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.17219\/acem\/40451","article-title":"Rehabilitation of the orofacial complex by means of a stimulating plate in children with down syndrome","volume":"24","author":"Matthews\u2010Brzozowska T","year":"2015","journal-title":"Adv Clin Exp Med"},{"key":"e_1_2_7_5_1","first-page":"442","article-title":"Orofacial regulation therapy in children with down syndrome, using the methods and appliances of castillo\u2010morales","volume":"57","author":"Hoyer H","year":"1990","journal-title":"ASDC J Dent Child"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12987-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20157"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22672"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.30.4.60q6841412763771"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3104\/reports.301"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182728"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-64402007000400014"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-014-9538-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12160"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjv054"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjt063"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12376"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2319\/062813-480.1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2006.00781.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/ode.61.1.39.46"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-1-2"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2319\/011006-16R.1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016359609006017"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/000163501750157117"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.28.1.buq243j955771h48"},{"key":"e_1_2_7_28_1","first-page":"13","article-title":"A longitudinal study of palatal plate therapy in children with down syndrome. 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