{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:14:03Z","timestamp":1788257643785,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate phenotypic differences in dental development between isolated oligodontia and oligodontia\u2010ectodermal dysplasia (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and sample population<\/jats:title><jats:p>A total of 129 patients diagnosed with isolated oligodontia and 22 patients with oligodontia as part of <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> were eligible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The phenotype of dental development was assessed for the frequency of missing a certain tooth, dental age, development of each tooth present, abnormal size and abnormal shape of teeth. The data were analysed building linear, ordinal and logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to patients with isolated oligodontia, patients with oligodontia\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> missed more frequently central incisors and second molars in both jaws, and lateral incisors in the mandible (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Oligodontia\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> was associated with delayed development of the permanent dentition (\u03b2\u00a0=\u00a0\u22120.10; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22120.17, \u22120.03). Specifically, the maxillary teeth: right central incisor, right lateral incisor, right second premolar and left second premolar were delayed approximately from 2 to 4 developmental stages. In addition, the left mandibular second premolar was 3 developmental stages delayed. Abnormal shape of teeth was 7 times more evident in patients with oligodontia\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> compared to patients with isolated oligodontia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a06.54; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.34, 18.28). The abnormal size of teeth was not a distinctive characteristic for oligodontia\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oligodontia\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> distinguishes from isolated oligodontia by more disturbances in dental development. The abnormal shape of incisors and canines in a patient with oligodontia can raise suspicions for accompanying ectodermal abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12214","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T05:16:05Z","timestamp":1514092565000},"page":"48-56","source":"Crossref","is-referenced-by-count":20,"title":["Disturbances of dental development distinguish patients with oligodontia\u2010ectodermal dysplasia from isolated oligodontia"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5537-067X","authenticated-orcid":false,"given":"B.","family":"Dhamo","sequence":"first","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Special Dental Care and Orthodontics Erasmus University Medical Centre  Rotterdam The Netherlands"},{"name":"The Generation R Study Group Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A. R.","family":"Kuijpers","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Biology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Balk\u2010Leurs","sequence":"additional","affiliation":[{"name":"Orthodontiepraktijk Amsterdam Zuid  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Boxum","sequence":"additional","affiliation":[{"name":"Orthodontiepraktijk Heerenveen  Heerenveen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. B.","family":"Wolvius","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Special Dental Care and Orthodontics Erasmus University Medical Centre  Rotterdam The Netherlands"},{"name":"The Generation R Study Group Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M.","family":"Ongkosuwito","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Special Dental Care and Orthodontics Erasmus University Medical Centre  Rotterdam The Netherlands"},{"name":"The Generation R Study Group Erasmus University Medical Centre  Rotterdam The Netherlands"},{"name":"Department of Orthodontics and Craniofacial Biology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"263","article-title":"Hypodontia\u2013a retrospective review of prevalence and etiology. 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