{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T06:48:50Z","timestamp":1765176530683,"version":"3.37.3"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T00:00:00Z","timestamp":1536624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim was to review the literature regarding genetic contributions to temporomandibular joint disorder (<jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content>) after our 2008 publication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and Sample Population<\/jats:title><jats:p>Literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>PubMed and <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> were used to obtain literature in any language regarding genes and <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content>, using the keywords \u201ctemporomandibular joint disorder\u201d and \u201ctemporomandibular joint dysfunction\u201d for studies published from 2009 to 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our search, 274 studies were found. We excluded 76 studies from animal models, 22 studies that were in vitro and 120 reports that were not cohort or case\u2010control studies. Of the 274 results, 56 articles were selected for this review. Genes that are suggested to contribute to <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content> included the ones related to disc and bone alterations as well as pain sensation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Currently, no evidence of associated genetic variants, which can determine the development of <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content> in individuals, could be translated to novel clinical management and public health strategies for patients suffering from <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12239","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T16:50:56Z","timestamp":1536684656000},"page":"186-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The many faces of genetic contributions to temporomandibular joint disorder: An updated review"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-6413","authenticated-orcid":false,"given":"Rafaela","family":"Scariot","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Universidade Positivo  Curitiba Brazil"},{"name":"Department of Oral and Maxillofacial Surgery Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola F. C. L.","family":"Corso","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Universidade Positivo  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline M.","family":"Sebastiani","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Universidade Positivo  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre R.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Oral Biology School of Dental Medicine University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12295"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2832"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516686562"},{"key":"e_1_2_6_5_1","first-page":"117","article-title":"Epidemiology and etiology of TMD","volume":"52","author":"Pereira FJ","year":"2004","journal-title":"Rev Gaucha Odontol"},{"issue":"2","key":"e_1_2_6_6_1","first-page":"114","article-title":"The additional value of a home physical therapy regimen versus patient education only for the treatment of myofascial pain of the jaw muscles: short\u2010term results of a randomized clinical trial","volume":"18","author":"Michelotti A","year":"2004","journal-title":"J Orofac Pain"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/15360288.2014.997853"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/1305-7456.175680"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7438326"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.09.010"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.09.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.10.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2017.03.024"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25593"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.06.014"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.11.004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12420"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025503"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.08.005"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513483471"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101896"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12146"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2016.07.010"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2016.06.010"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.12.013"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.09.009"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.43"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.1688"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1388-8"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4101"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-75"},{"key":"e_1_2_6_32_1","first-page":"2114589","article-title":"ACTN3 and ENPP1 contribute to sagittal craniofacial differences in humans","volume":"94","author":"Deeley K","year":"2015","journal-title":"J Dent Res"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2017.02.020"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152711794653751"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12089"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12273"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.1343"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2010.e50"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-016-0086-4"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/436067"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2015.2440"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.04.016"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00733.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.08.007"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2012.03.004"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.20242"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516678599"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2015.08.001"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2010.00803.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2008.11.003"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2012.05.030"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514552825"},{"key":"e_1_2_6_53_1","first-page":"1","article-title":"Expression of MMP\u201013 in human temporomandibular joint disc derangement and osteoarthritis","volume":"26","author":"Perotto JH","year":"2017","journal-title":"Cranio"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515599149"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.03.034"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctdb.2015.07.008"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144226"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12070"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2015.10.026"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.03830.x"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145002"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740310004603"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100325"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2015.01.004"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v028a15"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119526"},{"issue":"12","key":"e_1_2_6_67_1","first-page":"1485","article-title":"Expression of ADAMTS\u20105 in deformed human temporomandibular joint discs","volume":"23","author":"Matsumoto T","year":"2008","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2008.00426.x"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200305000-00016"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2012.05.014"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08843"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515595043"},{"issue":"4","key":"e_1_2_6_73_1","first-page":"260","article-title":"Association between estrogen levels and temporomandibular disorders: a systematic literature review","volume":"14","author":"Berger M","year":"2015","journal-title":"Prz Menopauzalny"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2006.12.004"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.11.012"}],"container-title":["Orthodontics &amp; Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Focr.12239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.12239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:56:10Z","timestamp":1694933770000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ocr.12239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,11]]},"references-count":74,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/ocr.12239"],"URL":"https:\/\/doi.org\/10.1111\/ocr.12239","archive":["Portico"],"relation":{},"ISSN":["1601-6335","1601-6343"],"issn-type":[{"type":"print","value":"1601-6335"},{"type":"electronic","value":"1601-6343"}],"subject":[],"published":{"date-parts":[[2018,9,11]]},"assertion":[{"value":"2018-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}