{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T19:54:28Z","timestamp":1770234868943,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Structured Abstract<\/jats:title>Objective<\/jats:title>To investigate parental age in relation to the severity of cleft diagnosis in a population\u2010based consecutive sample of individuals with clefts.<\/jats:p><\/jats:sec>Setting\/Sample<\/jats:title>Retrospective, consecutive.<\/jats:p><\/jats:sec>Material\/Methods<\/jats:title>The sample comprised 545 consecutive cases with nonsyndromic clefts (437 individuals with cleft lip with\/without cleft palate [CL<\/jats:styled-content> \u00b1 P] and 106 individuals with isolated cleft palate [CP<\/jats:styled-content>]) and parental ages recorded. The groups were subdivided according to the extent\/severity of cleft. Unilateral clefts were divided according to left\/right sidedness. Logistic regression was used to analyse the association between parental age and risk of severe cleft separately for CL<\/jats:styled-content> \u00b1 P and CP<\/jats:styled-content>, as well as between parental age and risk of right\u2010sided cleft.<\/jats:p><\/jats:sec>Results<\/jats:title>In CL<\/jats:styled-content> \u00b1 P, the risk of a complete cleft in the offspring increases with maternal age when the paternal age exceeds approximately 29\u00a0years. Moreover, the risk is higher when both parents are old than when both parents are young. In CP<\/jats:styled-content>, no statistically significant results were identified. However, there were clear trends that indicated a similar pattern as that for CL<\/jats:styled-content> \u00b1 P. No association was identified between increased parental age and the sidedness of clefts.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Parental age seems to contribute to cleft severity, as older parents showed a higher risk of having offspring with a complete cleft than younger parents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12241","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T09:54:07Z","timestamp":1536227647000},"page":"236-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Parental age in relation to the severity of cleft lip and\/or palate"],"prefix":"10.1111","volume":"21","author":[{"given":"Nuno V.","family":"Hermann","sequence":"first","affiliation":[{"name":"Section of Pediatric Dentistry and Clinical Genetics School of Dentistry Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"3D Craniofacial Image Research Laboratory (School of Dentistry, University of Copenhagen, Centre of Head and Orthopaedics Copenhagen University Hospital Rigshospitalet; and Department of Applied Mathematics and Computer Science Technical University of Denmark) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tron A.","family":"Darvann","sequence":"additional","affiliation":[{"name":"3D Craniofacial Image Research Laboratory (School of Dentistry, University of Copenhagen, Centre of Head and Orthopaedics Copenhagen University Hospital Rigshospitalet; and Department of Applied Mathematics and Computer Science Technical University of Denmark) Copenhagen Denmark"},{"name":"Department of Oral and Maxillofacial Surgery Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Munch","sequence":"additional","affiliation":[{"name":"Section of Biostatistics Department of Public Health Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Kreiborg","sequence":"additional","affiliation":[{"name":"Section of Pediatric Dentistry and Clinical Genetics School of Dentistry Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"3D Craniofacial Image Research Laboratory (School of Dentistry, University of Copenhagen, Centre of Head and Orthopaedics Copenhagen University Hospital Rigshospitalet; and Department of Applied Mathematics and Computer Science Technical University of Denmark) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"341","article-title":"Racial differences in cephalometric measurements and incidence of cleft lip with or without cleft palate","volume":"5","author":"Chung CS","year":"1985","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980827)79:1<42::AID-AJMG11>3.0.CO;2-M"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511402083"},{"key":"e_1_2_6_5_1","first-page":"258","article-title":"Cleft lip and palate in Denmark, 1976\u20101981: epidemiology, variability, and early somatic development","volume":"25","author":"Jensen BL","year":"1988","journal-title":"Cleft Palate J"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(1999)036<0096:TCDFCP>2.3.CO;2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1597\/03-139.1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2015.05.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2011.10.002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.128875"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3462-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000158745.84019.c2"},{"key":"e_1_2_6_13_1","first-page":"312e 3","article-title":"Parental age and mutation","volume":"269","author":"Penrose LS","year":"1955","journal-title":"Lancet"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.111.134668"}],"container-title":["Orthodontics & Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Focr.12241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.12241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:55:33Z","timestamp":1694933733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ocr.12241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,6]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/ocr.12241"],"URL":"https:\/\/doi.org\/10.1111\/ocr.12241","archive":["Portico"],"relation":{},"ISSN":["1601-6335","1601-6343"],"issn-type":[{"value":"1601-6335","type":"print"},{"value":"1601-6343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,6]]},"assertion":[{"value":"2017-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}