{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:02:30Z","timestamp":1787313750575,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Structured Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n The morbidity and mortality associated with the Marfan Syndrome (\n MFS<\/jats:styled-content>\n ) warrant timely diagnosis and intervention that can improve long\u2010term prognosis. The aim of this study was to test the hypothesis that a distinct craniofacial morphology exists for patients with\n MFS<\/jats:styled-content>\n that can be described quantitatively and qualitatively.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Subjects with a positive diagnosis of\n MFS<\/jats:styled-content>\n were recruited for this study (N\u00a0=\u00a036). Craniofacial anthropometric measurements were made on each subject and compared to established norms of age\u2010 and sex\u2010matched controls using\n z<\/jats:italic>\n \u2010scores calculated for measurements of\n MFS<\/jats:styled-content>\n patients. Lateral and frontal photographs were obtained to make qualitative assessments and describe facial features of subjects, and a clinical examination was completed to document occlusal relationships.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The subjects were primarily female (58%) ranging in age between 4 and 57\u00a0years (mean age 10.7\u00a0\u00b1\u00a06.0\u00a0years). Comparison of craniofacial measurements revealed that for 10 of the 12 measurements, \u226565% of the study population had a\n z<\/jats:italic>\n \u2010score of\u00a0\u00b1\u00a02 and fell within the normal range for facial dimension. For 2 of the 12 measurements, over half of the subjects fell outside of the normal range (\n z<\/jats:italic>\n \u2010score\u00a0<\u00a0\u22122 or\u00a0>\u00a02) for facial dimension. Specifically, the majority of participants resided in the supernormal category for biocular width and the subnormal category for width of the face. Photographic assessment revealed retrognathia (54%) and down\u2010slanting palpebral fissures (62%) were most prevalent in\n MFS<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our data suggest there are quantitative differences in the facial morphology of patients with\n MFS<\/jats:styled-content>\n when compared to a control population.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ocr.12295","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T03:31:27Z","timestamp":1557459087000},"page":"56-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Craniofacial characterization of Marfan Syndrome"],"prefix":"10.1111","volume":"22","author":[{"given":"Christian M.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Orthodontics The University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Spruiell","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Texas A and M University College of Dentistry Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Wiesen","sequence":"additional","affiliation":[{"name":"The Odum Institute University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz A.","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Department of Dental Ecology UNC Craniofacial Center The University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Vann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry The University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8133-873X","authenticated-orcid":false,"given":"Sylvia A.","family":"Frazier\u2010Bowers","sequence":"additional","affiliation":[{"name":"Department of Orthodontics The University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"GeneReviews(R)","author":"Dietz HC","year":"1993"},{"key":"e_1_2_6_3_1","unstructured":"Marfan Syndrome. 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