{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:02:31Z","timestamp":1791298951084,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K11965"],"award-info":[{"award-number":["17K11965"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K09859"],"award-info":[{"award-number":["18K09859"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K09860"],"award-info":[{"award-number":["18K09860"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K09916"],"award-info":[{"award-number":["18K09916"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H06312"],"award-info":[{"award-number":["18H06312"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Structured Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Rapid maxillary expansion (<jats:styled-content style=\"fixed-case\">RME<\/jats:styled-content>) improves nasal airway ventilation in non\u2010cleft palate children. Children with unilateral cleft lip and palate (<jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content>) may have nasal obstruction and experience an increased risk of obstructive sleep apnoea. The effect of <jats:styled-content style=\"fixed-case\">RME<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content> children is unclear. This retrospective study evaluated <jats:styled-content style=\"fixed-case\">RME<\/jats:styled-content>\u2010induced changes in ventilation parameters in children with <jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content> using computational fluid dynamics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and Sample Population<\/jats:title><jats:p>Nineteen patients (10 boys, mean age 10.7\u00a0years) who required <jats:styled-content style=\"fixed-case\">RME<\/jats:styled-content> had cone\u2010beam computed tomography images taken before and after <jats:styled-content style=\"fixed-case\">RME<\/jats:styled-content>. Twenty control participants (11 boys, mean age 11.1\u00a0years) received regular orthodontic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nasal airway ventilation parameters (air pressure, air velocity and airflow rate) were analysed via computational fluid dynamics, and nasal cross\u2010sectional area (<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>) was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maximum pressure, velocity and nasal resistance were significantly reduced by <jats:styled-content style=\"fixed-case\">RME<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content> group. Air flow rate and <jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content> on the cleft side significantly were increased by <jats:styled-content style=\"fixed-case\">RME<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In children with <jats:styled-content style=\"fixed-case\">UCLP<\/jats:styled-content>, increasing the quantity of airflow and <jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content> on the cleft side by <jats:styled-content style=\"fixed-case\">RME<\/jats:styled-content> substantially improved nasal ventilation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12311","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T12:04:53Z","timestamp":1553601893000},"page":"201-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Rapid maxillary expansion effects of nasal airway in children with cleft lip and palate using computational fluid dynamics"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3919-4714","authenticated-orcid":false,"given":"Tomonori","family":"Iwasaki","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry Graduate School of Medical and Dental Sciences Kagoshima University Kagoshima\u2010City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Yanagisawa\u2010Minami","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Graduate School of Medical 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