{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:50:00Z","timestamp":1788900600030,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008364","name":"Tandl\u00e6geforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the impact of cleft severity and timing of hard palate repair on palatal dimensions in unilateral cleft lip and palate (UCLP) children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and sample population<\/jats:title><jats:p>Single\u2010centre analysis within a multicenter RCT of primary surgery; 122 UCLP randomized to early hard palate closure (EHPC) at 12\u00a0months or delayed hard palate closure (DHPC) at 36\u00a0months; 28 frequency\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Linear measurements of palatal height, width and length were performed on 116 digital models of UCLP subjects (8.21\u00a0years, SD\u00a0=\u00a00.53) and 28 models of non\u2010cleft individuals (8.44\u00a0years SD\u00a0=\u00a00.72). Cleft dimensions at infancy (mean 1.8\u00a0months) were considered. In a pilot study, shell\u2010to\u2010shell distances between the 3D cleft palate objects and a reference mesh were calculated and differences between the groups assessed. Morphological differences were visualized using colour mapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, UCLP subjects presented a higher palate at the level of the anterior scar (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.002), but generally a lower palate in the middle region (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). Comparing UCLP subgroups, the DHPC subjects showed a flatter palate posteriorly (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.048) and the EHPC group exhibited more transversal constriction (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.003 at M1 level). 3D analysis revealed a shallower palate in the DHPC group both in the middle (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.002) and the posterior part (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.008). Anterior cleft severity correlated negatively with palatal height (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Unilateral cleft lip and palate palates differ from controls in width and height. DHPC may represent an advantage for the transversal dimension, but a disadvantage for palatal height. Infant cleft dimensions partially explain differences in palatal height.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12318","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T19:45:09Z","timestamp":1557171909000},"page":"270-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Palatal morphology in unilateral cleft lip and palate patients: Association with infant cleft dimensions and timing of hard palate repair"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-2960","authenticated-orcid":false,"given":"Susanna","family":"Botticelli","sequence":"first","affiliation":[{"name":"Section of Orthodontics Aarhus University Aarhus Denmark"},{"name":"Cleft Lip and Palate Department Institut for Komunikation og Handikap (IKH) Aarhus 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Erik","family":"N\u00f8rholt","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Aarhus University Hospital Aarhus Denmark"},{"name":"Section of Oral Surgery and Oral Pathology Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Dalstra","sequence":"additional","affiliation":[{"name":"Section of Orthodontics Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo M.","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Section of Orthodontics Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Klit","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Section of Orthodontics Aarhus University Aarhus Denmark"},{"name":"Department of Oral and Maxillofacial Surgery Aarhus University Hospital Aarhus 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