{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:10:49Z","timestamp":1777421449855,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002050","name":"Delta Dental Foundation","doi-asserted-by":"publisher","award":["Student Research Award (to S.J.B)"],"award-info":[{"award-number":["Student Research Award (to S.J.B)"]}],"id":[{"id":"10.13039\/100002050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005648","name":"American Association of Orthodontists Foundation","doi-asserted-by":"publisher","award":["Biomedical Research Award (to N.E.H.)"],"award-info":[{"award-number":["Biomedical Research Award (to N.E.H.)"]}],"id":[{"id":"10.13039\/100005648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The goal of this study was to investigate potential negative sequelae of orthodontic force application \u00b1delivery of an osteoclast inhibitor, recombinant osteoprotegerin protein (OPG\u2010Fc), on periodontal tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and Sample Population<\/jats:title><jats:p>Sprague Dawley rats from a commercial supplier were investigated in a laboratory setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Rats were randomly divided into four groups (n\u00a0=\u00a07 each): one group with no orthodontic appliances and injected once prior to the experimental period with empty polymer microspheres, one group with orthodontic appliances and injected once with empty microspheres, one group with orthodontic appliances and injected once with polymer microspheres containing 1\u00a0mg\/kg of OPG\u2010Fc, and one group with orthodontic appliances and injected with non\u2010encapsulated 5\u00a0mg\/kg of OPG\u2010Fc every 3\u00a0days during the experimental period. The animals were euthanized after 28\u00a0days of tooth movement for histomorphometric analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Root resorption, PDL area and widths were similar in animals without appliances and animals with appliances plus high\u2010dose OPG\u2010Fc. PDL blood vessels were compressed and decreased in number in all animals that received orthodontic appliances, regardless of OPG\u2010Fc. Hyalinization was significantly increased only in animals with orthodontic appliances plus multiple injections of 5\u00a0mg\/kg non\u2010encapsulated OPG\u2010Fc when compared to animals without appliances.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results of this study indicate that while pharmacological modulation of tooth movement through osteoclast inhibition is feasible when delivered in a locally controlled low\u2010dose manner, high\u2010dose levels that completely prevent tooth movement through bone may decrease local blood flow and increase the incidence of hyalinization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12350","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T15:55:28Z","timestamp":1570550128000},"page":"35-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of pharmacologic inhibition of tooth movement on periodontal and tooth root tissues during orthodontic force application"],"prefix":"10.1111","volume":"23","author":[{"given":"Sarah J.","family":"Baxter","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry School of Dentistry University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Sydorak","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry School of Dentistry University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter X.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biologic and Materials Sciences School of Dentistry University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2632-0841","authenticated-orcid":false,"given":"Nan 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