{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:48:19Z","timestamp":1747187299843,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2015HM022"],"award-info":[{"award-number":["ZR2015HM022"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of the present work was to investigate the association between <jats:italic>forkhead box E1 (FOXE1)<\/jats:italic> and the risk of non\u2010syndromic cleft lip with or without cleft palate (NSCL\/P).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Relevant studies were searched in several professional databases up to 31 July 2019. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using a fixed\u2010effect model or a random\u2010effect model to analyse the relationship between <jats:italic>FOXE1<\/jats:italic> polymorphisms and NSCL\/P.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of four single nucleotide polymorphisms (SNPs), including rs3758249, rs4460498, rs1443434 and rs10217225, were analysed. The overall findings showed that <jats:italic>FOXE1<\/jats:italic> rs4460498 was statistically associated with NSCL\/P (including cleft lip with or without cleft palate (CL\/P) and cleft palate only (CPO)). Genotypes CC and CT of rs4460498 were significantly more closely correlated with NSCL\/P (including CL\/P and CPO) than genotype TT (NSCL\/P: TT vs CC, OR\u00a0=\u00a00.630, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.000; TT vs TC\u00a0+\u00a0CC, OR\u00a0=\u00a00.775, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.020; CL\/P: TT vs CC, OR\u00a0=\u00a00.664, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.000; TT vs TC\u00a0+\u00a0CC, OR\u00a0=\u00a00.738, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006. CPO: TT vs CC, OR\u00a0=\u00a00.761, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.027; TT vs TC\u00a0+\u00a0CC, OR\u00a0=\u00a00.792, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.045). For rs10217225, only the TT genotype might have contributed to the elevated risk of CL\/P (TT vs CC OR\u00a0=\u00a02.236, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.000). The other <jats:italic>FOXE1<\/jats:italic> polymorphisms were not associated with NSCLP, CL\/P or CPO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The meta\u2010analysis provided confirmation that the polymorphism of <jats:italic>FOXE1<\/jats:italic> rs10217225 was correlated with an increased risk of CL\/P, and the polymorphism of <jats:italic>FOXE1<\/jats:italic> rs4460498 was a protective factor for NSCL\/P, including CLP and CPO.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12366","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T11:35:53Z","timestamp":1579174553000},"page":"151-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between <i>forkhead box E1<\/i> polymorphisms and risk of non\u2010syndromic cleft lip with or without cleft palate: A 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1519-8924","authenticated-orcid":false,"given":"Ning","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Affiliated Hospital of Qingdao University Qingdao 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without cleft palate (NSCL\/P) and genetic polymorphisms of BMP4 TGF\u03b2\u20103 FOXE1 MTHFR in Guangdong province.Guangzhou:Medical University Press;2013."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20687"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37871"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514523987"},{"issue":"4","key":"e_1_2_6_15_1","first-page":"490","article-title":"Association between FOXE1 polymorphisms and non\u2010syndromic cleft lip with or without cleft palate in Ningxia Hui and Han population","volume":"28","author":"Zhang GX","year":"2012","journal-title":"J Pract Stomatol"},{"key":"e_1_2_6_16_1","first-page":"6390545","article-title":"FOXE1 mutation screening in a case with cleft lip, hypothyroidism, and thyroid carcinoma: a new syndrome?","volume":"2017","author":"Mendieta\u2010Zeron H","year":"2017","journal-title":"Case Rep 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