{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:07:10Z","timestamp":1790194030628,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To use morphometric methods to investigate the size and shape of the sella turcica in children with unilateral cleft lip and palate (UCLP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and sample population<\/jats:title><jats:p>Fifty\u2010six healthy children with non\u2010syndromic UCLP, from a major paediatric teaching hospital, with lateral cephalograms taken prior to alveolar bone grafting, were compared with an age\u2010 and sex\u2010matched control group of healthy children without orofacial clefts, with lateral cephalograms taken prior to orthodontic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In this cross\u2010sectional study, conventional measurements were performed on the sella turcica to measure width, height and area on lateral cephalograms. Sella shape was also analysed using 11 points defining the sella turcica contours, using geometric morphometrics. Procrustes superimposition was used to register all sella contour tracings to calculate average sella shape. Principal component analysis was applied to the residuals of the point coordinates, and principal components (PCs) of shape were extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant differences between the UCLP and control groups were found for sella posterior height, midpoint height, maximum height and area, where all of these were smaller in children with UCLP. Principal component analysis revealed that the first two PCs accounted for 84.7% of total shape variance. There was a statistically significant difference in sella shape between children with UCLP and control children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In children with UCLP, the sella turcica is shorter and with a smaller surface area when compared to\u00a0matched non\u2010cleft children. Moreover, sella turcica shape, when disregarding size, seems to differ to that of non\u2010cleft children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12380","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T12:14:50Z","timestamp":1587212090000},"page":"398-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sella turcica morphometrics in children with unilateral cleft lip and palate"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6741-6922","authenticated-orcid":false,"given":"Gregory S.","family":"Antonarakis","sequence":"first","affiliation":[{"name":"Division of Orthodontics University Clinics of Dental Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Huanca Ghislanzoni","sequence":"additional","affiliation":[{"name":"Division of Orthodontics University Clinics of Dental Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio C.","family":"La Scala","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Department of Pediatrics University Center of Pediatric Surgery of Western Switzerland Geneva University Hospitals Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjm048"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/26.6.597"},{"key":"e_1_2_8_4_1","first-page":"43","article-title":"The study of shape and size of normal sella turcica in cephalometric radiographs","volume":"31","author":"Choi WJ","year":"2001","journal-title":"Korean J Oral Maxillofac Radiol"},{"key":"e_1_2_8_5_1","first-page":"714","article-title":"Bridging and dimensions of sella turcica in subjects treated by surgical\u2010orthodontic means or orthodontics only","volume":"75","author":"Jones RM","year":"2005","journal-title":"Angle Orthod"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002698"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2003.05.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(96)70057-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjs091"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-014-0609-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1597\/07-058.1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12219"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1597\/04-104r.1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653125.2017.1343221"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1597\/13-258"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000453526"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/02844318709083572"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1992_029_0475_gcbcwc_2.3.co_2"},{"key":"e_1_2_8_19_1","first-page":"158","article-title":"The timing of height and weight deficits in twins discordant for cleft of the lip and\/or palate","volume":"14","author":"Hunter WS","year":"1977","journal-title":"Cleft Palate J"},{"key":"e_1_2_8_20_1","first-page":"473","article-title":"Longitudinal study of body height, radius length and skeletal maturity in Danish boys with cleft lip and palate","volume":"91","author":"Jensen BL","year":"1983","journal-title":"Scand J Dent Res"},{"key":"e_1_2_8_21_1","first-page":"258","article-title":"Cleft lip and palate in Denmark, 1976\u20131981: epidemiology, variability, and early somatic development","volume":"25","author":"Jensen BL","year":"1988","journal-title":"Cleft Palate J"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005721-199909000-00009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.161.8.753"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.53.12.952"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)81141-X"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.15171\/jarcm.2015.036"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20656"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1999_036_0486_pnmiiw_2.3.co_2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000169693.87591.9B"},{"key":"e_1_2_8_30_1","first-page":"157","article-title":"The hybrid palatoplasty: a preliminary report","volume":"4","author":"Gillet DA","year":"1996","journal-title":"Canadian J Plast Surg"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(83)90322-6"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3562916"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1209"}],"container-title":["Orthodontics &amp; Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Focr.12380","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.12380","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ocr.12380","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.12380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:39:11Z","timestamp":1693813151000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ocr.12380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,7]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/ocr.12380"],"URL":"https:\/\/doi.org\/10.1111\/ocr.12380","archive":["Portico"],"relation":{},"ISSN":["1601-6335","1601-6343"],"issn-type":[{"value":"1601-6335","type":"print"},{"value":"1601-6343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,7]]},"assertion":[{"value":"2019-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}