{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:39:12Z","timestamp":1773693552044,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Surgical closure of the cleft damages nerves and blood supply in the area and may possibly negatively influence dental development in children with cleft lip and palate (CLP). Previous studies of the permanent first mandibular molar (M1<jats:sub>inf<\/jats:sub>) in children with unilateral complete CLP found delayed maturation and decreased follicle\/crown width before any surgical interventions. This study aimed to investigate if these findings are representative for the total population of individuals born with CLP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and sample population<\/jats:title><jats:p>A population\u2010based consecutive longitudinal sample of 224 children with clefts: 183 with CLP (66 with complete [47 unilateral, 19 bilateral], 117 with incomplete [70 unilateral, 47 bilateral], and 41 with unilateral incomplete cleft lip (controls), was examined pre\u2010 and post\u2010lip closure (at 2 and 22\u00a0months of age).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In lateral cephalometric X\u2010rays (obtained as part of a standard treatment protocol), M1<jats:sub>inf<\/jats:sub> follicle maturation and follicle\/crown width were assessed. Mantel\u2010Haenszel test and Pearson's correlation coefficient R were used to describe relationships. Differences between group means were tested using Wilcoxon rank sum test. Significance level was set to 5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follicle maturation was significantly delayed in all groups with CLP compared to that in controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). Follicle and crown width were significantly reduced in all CLP groups compared with those in controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). Sex did not influence these variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Delayed follicle maturation and decreased follicle\/crown\/tooth size were found to be part of the congenital traits characterizing individuals with all types of CLP and not a result of surgical iatrogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12386","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T09:43:16Z","timestamp":1589017396000},"page":"432-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Delayed maturation and reduced crown width of the permanent first mandibular molar in all subgroups of cleft lip and palate"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-8571","authenticated-orcid":false,"given":"Nuno V.","family":"Hermann","sequence":"first","affiliation":[{"name":"Pediatric Dentistry and Clinical Genetics School of Dentistry Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"3D Craniofacial Image Research Laboratory (School of Dentistry, University of Copenhagen; Centre of Head and Orthopaedics, Copenhagen University Hospital Rigshospitalet; and Department of Applied Mathematics and Computer Science, Technical University of Denmark) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tron A.","family":"Darvann","sequence":"additional","affiliation":[{"name":"3D Craniofacial Image Research Laboratory (School of Dentistry, University of Copenhagen; Centre of Head and Orthopaedics, Copenhagen University Hospital Rigshospitalet; and Department of Applied Mathematics and Computer Science, Technical University of Denmark) Copenhagen Denmark"},{"name":"Department of Oral and Maxillofacial Surgery Centre of Head and Orthopaedics, Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Kreiborg","sequence":"additional","affiliation":[{"name":"Pediatric Dentistry and Clinical Genetics School of Dentistry Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"3D Craniofacial Image Research Laboratory (School of Dentistry, University of Copenhagen; Centre of Head and Orthopaedics, Copenhagen University Hospital Rigshospitalet; and Department of Applied Mathematics and Computer Science, Technical University of Denmark) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(86)90022-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(2001)038<0374:HATFIG>2.0.CO;2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/02844310500223945"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1597\/07-064.1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjp156"},{"issue":"4","key":"e_1_2_7_7_1","first-page":"177","article-title":"The size of the dentition in complete cleft lip and palate","volume":"8","author":"Foster TD","year":"1971","journal-title":"Cleft Palate J"},{"issue":"1","key":"e_1_2_7_8_1","first-page":"36","article-title":"Odontometrics of the permanent teeth in cleft lip and palate systemic size reduction and amplified asymmetry","volume":"26","author":"Werner S","year":"1989","journal-title":"Cleft Palate J"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjn073"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1597\/05-197.1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2006.05.048"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2319\/072013-526.1"},{"issue":"1","key":"e_1_2_7_13_1","first-page":"15","article-title":"On asymmetric development of the first and second permanent molars in children with cranio\u2010facial anomalies","volume":"68","author":"Haataja J","year":"1972","journal-title":"Proc Finn Dent Soc"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(79)90062-1"},{"issue":"4","key":"e_1_2_7_15_1","first-page":"307","article-title":"Tooth size in children with cleft lip and palate","volume":"20","author":"Peterka M","year":"1983","journal-title":"Cleft Palate J"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1597\/07-078.1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0819-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1597\/11-228"},{"issue":"2","key":"e_1_2_7_19_1","first-page":"58","article-title":"A comparative study of tooth formation in the permanent dentition of Finnish children with cleft lip and palate. 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