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Using multiple logistic regression analysis, it was found that the T\u2010allele of rs12853659 (EDA) and the G\u2010allele of rs2428151 (EDA) were both associated with a higher risk of hypodontia (odds ratio, OR\u00a0=\u00a02.79, 95% CI\u00a0=\u00a01.11\u20107.01; and OR\u00a0=\u00a02.87, 95% CI\u00a0=\u00a01.04\u20107.94, respectively). The G\u2010allele of rs2520378 (EDA) showed a protective effect with an OR of 0.61 (95% CI\u00a0=\u00a00.38\u20100.99). The EDA SNP findings were consistent with previous reports included in a meta\u2010analysis. No associations were found with the <jats:italic>PAX9, AXIN2<\/jats:italic> and <jats:italic>MSX1<\/jats:italic> genes, after adjusting for sex and ethnicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Common variants of the <jats:italic>EDA<\/jats:italic> genes are associated with specific phenotypes of non\u2010syndromic hypodontia, thus confirming their role in the regulatory pathways of normal tooth development. However, larger samples are needed to investigate the association further.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12419","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T20:05:25Z","timestamp":1597003525000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Common variants of <i>EDA<\/i> are associated with non\u2010syndromic hypodontia"],"prefix":"10.1111","volume":"24","author":[{"given":"Azza H.","family":"Al\u2010Ani","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Sir John Walsh Research Institute University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Antoun","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Sir John Walsh Research Institute University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Thomson","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Sir John Walsh Research Institute University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Topless","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Dentistry University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony R.","family":"Merriman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Dentistry University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4516-647X","authenticated-orcid":false,"given":"Mauro","family":"Farella","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Sir John Walsh Research Institute University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513487210"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2004.00158.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36571"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00210412"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.8.551"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-417"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.09.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700715"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517750109"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514523986"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2008.06.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32801"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.127"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34045"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(2003)040<0274:GASOCL>2.0.CO;2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00056-013-0138-z"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2007.00407.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/386293"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-005-0353-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511401622"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.01.005"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.5152\/jtgga.2015.15174"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2013.822547"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2005.02.003"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517711156"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.1993.tb01624.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4623-1"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.174"},{"key":"e_1_2_7_30_1","unstructured":"Infinium genotyping data analysis. c2010\u20102014. 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