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Nine SNPs in<jats:italic>BMP2<\/jats:italic>,<jats:italic>BMP4<\/jats:italic>,<jats:italic>SMAD6, RUNX2, WNT3A<\/jats:italic>and<jats:italic>WNT11<\/jats:italic>were genotyped. Chi\u2010squared test was used to compare genotypes among the groups. Multifactor dimensionality reduction (MDR) and binary logistic regression analysis, both using gender and age as co\u2010variables, were also used. We performed Bonferroni correction for multiple testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant associations at<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05 were observed for SNPs rs1005464 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.042) and rs235768 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.021) in<jats:italic>BMP2<\/jats:italic>with mandibular retrognathism and for rs59983488 (<jats:italic>RUNX2<\/jats:italic>) with maxillary protrusion (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) as well as for rs708111 (<jats:italic>WNT3A<\/jats:italic>) with skeletal class III (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02; dominant model), rs1533767 (<jats:italic>WNT11<\/jats:italic>) with a brachyfacial skeletal pattern (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01, OR\u00a0=\u00a00.10; dominant model) and for rs3934908 (<jats:italic>SMAD6<\/jats:italic>) with prognathism (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02; recessive model). After the Bonferroni correction, none of the SNPs remained associated. The MDR predicted some interaction for skeletal class II, dolichofacial and brachyfacial phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that SNPs in<jats:italic>BMP2, BMP4, SMAD6, RUNX2, WNT3A<\/jats:italic>and<jats:italic>WNT11<\/jats:italic>could be involved in the aetiology of sagittal and vertical malocclusions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12433","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T18:54:10Z","timestamp":1602960850000},"page":"277-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Potential interactions among single nucleotide polymorphisms in bone\u2010 and cartilage\u2010related genes in skeletal malocclusions"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-2526","authenticated-orcid":false,"given":"Erika 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