{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:15:57Z","timestamp":1779164157952,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This investigation evaluates the evidence of case\u2010based reasoning (CBR) in providing additional information on the prediction of future Class III craniofacial growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings and sample population<\/jats:title><jats:p>The craniofacial characteristics of 104 untreated Class III subjects (7\u201017\u00a0years of age), monitored with two lateral cephalograms obtained during the growth process, were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Data were compared with the skeletal characteristics of subjects who showed a high degree of skeletal imbalance (\u2018prototypes\u2019) obtained from a large data set of 1263 Class III cross\u2010sectional subjects (7\u201017\u00a0years of age).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The degree of similarity of longitudinal subjects with the most unbalanced prototypes allowed the identification of subjects who would develop a subsequent unfavourable skeletal growth (accuracy: 81%). The angle between the palatal plane and the sella\u2010nasion line (PP\u2010SN angle) and the Wits appraisal were two additional craniofacial features involved in the early prediction of the adverse progression of the Class III skeletal imbalance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Case\u2010based reasoning methodology, which uses a personalized inference method, may bring additional information to approximate the skeletal progression of Class III malocclusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12466","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T21:11:43Z","timestamp":1610572303000},"page":"163-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic approach to Class III malocclusion through case\u2010based reasoning"],"prefix":"10.1111","volume":"24","author":[{"given":"Pietro","family":"Auconi","sequence":"first","affiliation":[{"name":"Private practice of Orthodontics Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ennio","family":"Ottaviani","sequence":"additional","affiliation":[{"name":"Department of Mathematics Universit\u00e0 degli Studi di Genova Genoa Italy"},{"name":"OnAIR Ltd Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Barelli","sequence":"additional","affiliation":[{"name":"OnAIR Ltd Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Giuntini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Orthodontics Universit\u00e0 degli Studi di Firenze Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"McNamara","sequence":"additional","affiliation":[{"name":"Thomas M and Doris Graber Endowed Professor Emeritus Department of Orthodontics and Pediatric Dentistry School of Dentistry University of Michigan Ann Arbor MI USA"},{"name":"Professor Emeritus of Cell and Developmental Biology School of Medicine Research Professor Emeritus Center for Human Growth and Development University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2072-460X","authenticated-orcid":false,"given":"Lorenzo","family":"Franchi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Orthodontics Universit\u00e0 degli Studi di Firenze Florence Italy"},{"name":"Thomas M. 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