{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:28:30Z","timestamp":1782865710991,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T00:00:00Z","timestamp":1614470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To perform a 3D cephalometric analysis of the craniofacial characteristics of patients with pycnodysostosis and compare this with a matched control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and Sample population<\/jats:title><jats:p>This cross\u2010sectional descriptive study assessed eight CBCTs obtained in patients with pycnodysostosis (4 males, 4 females, mean age: 31.8 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Eight Danish patients with pycnodysostosis were seen at the University's Orthodontic Clinic. All CBCTs were analysed using the Mimics 21.0 software (Materialise\u00ae, Belgium) and compared with a control group (6 males, 8 females, mean age: 33.6 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Interclass correlation coefficient showed excellent intra\u2010rater reliability (&gt; 0.93). All measurements in the 3D cephalometric analysis revealed statistical significance (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) when compared with controls. Patients with pycnodysostosis generally had significantly smaller maxilla in the transverse (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), sagittal (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.002) and vertical (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) dimensions. Their mandibles were also smaller vertically (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and in length (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Gonial angle was significantly larger than controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), while mandibular volumes were considerably smaller (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with pycnodysostosis have significantly smaller jaws in the vertical, sagittal and transverse dimensions compared with controls. Furthermore, the gonial angle was significantly larger, while the volume of the mandible was significantly smaller.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12479","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T09:01:28Z","timestamp":1613811688000},"page":"568-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Three\u2010dimensional analysis of craniofacial morphology in patients with pycnodysostosis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4995-1934","authenticated-orcid":false,"given":"Nikolaos","family":"Ferlias","sequence":"first","affiliation":[{"name":"Section of Orthodontics Department of Dentistry and Oral Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Gj\u00f8rup","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Center for Oral Health in Rare Diseases Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Aagaard Doherty","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Nordsj\u00e6llands Hospital Hillerod Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Haagerup","sequence":"additional","affiliation":[{"name":"NIDO Denmark Hospital Unit West and Institute of Clinical Medicine Faculty of Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Klit Pedersen","sequence":"additional","affiliation":[{"name":"Section of Orthodontics Department of Dentistry and Oral Health Aarhus University Aarhus Denmark"},{"name":"Department of Oral and Maxillofacial Surgery Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-018-2233-8"},{"key":"e_1_2_9_3_1","unstructured":"Orpha.net. 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