{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:48:42Z","timestamp":1747187322803,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Williams\u2010Beuren syndrome (WBS) is caused by a microdeletion on chromosome 7q11\u201023 and clusters a variety of systemic affectations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate whether 3D facial scans can detect WBS by objectively addressing their craniofacial, skeletal and dental characteristics, compared with those of a non\u2010affected control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>3D facial surface scans of 17 WBS individuals and 33 normal developing patients were analysed. Additionally, cephalometric and panoramic radiographs of subjects with WBS were compared with those of non\u2010affected individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 3D surface scans showed significant facial differences around the nose and mouth area. The cephalometric aspects of individuals with WBS differed mainly at the lower incisor region. Additionally, hypoplastic tooth morphology seems to be more often present in WBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>3D images are a non\u2010invasive, efficient method to observe facial anomalies and facilitate an early diagnosis of WBS. Additionally, the analysis of the cephalometric and panoramic images revealed significant differences in dental characteristics. Together with early diagnosis through 3D images, these can help in the establishment of adequate medical, dental and orthodontic treatment planning.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12541","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T18:49:15Z","timestamp":1633978155000},"page":"359-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Determination of craniofacial and dental characteristics of individuals with Williams\u2010Beuren syndrome by using 3D facial scans and radiographs"],"prefix":"10.1111","volume":"25","author":[{"given":"Florence","family":"Danneels","sequence":"first","affiliation":[{"name":"Department of Oral Health Sciences\u2010Orthodontics KU Leuven and Dentistry University Hospitals Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Verdonck","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences\u2010Orthodontics KU Leuven and Dentistry University Hospitals Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karlijne","family":"Indencleef","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering \u2013 Medical Imaging Research Center KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Declerck","sequence":"additional","affiliation":[{"name":"Department of oral Health Sciences \u2010 Population Studies in Oral Health &amp; 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