{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T15:31:16Z","timestamp":1769959876233,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to compare the craniofacial and neurocranial morphology of adults with osteogenesis imperfecta (OI) with controls and to elucidate whether osseous origin impacts on morphological deviations in OI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fifty\u2010four adults (mean age 45.8) with OI type I, 14 adults (mean age 42.6) with OI types III\/IV and 49 adult controls (mean age 41.0) were included. All participants had European ethnicity. Cranial morphology was assessed by 2D\u2010cephalometry. Comparison between groups was made by multiple regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparison between OI groups and controls: (1) Dimension of the maxilla and mandible, respectively was reduced (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01), and in relation to the posterior cranial base, the maxilla was retro\u2010positioned (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and the mandible was prognathic (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). (2) The anterior face height was reduced (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.04), and in OI types III\/IV only, the maxilla was posteriorly inclined (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). (3) Anterior cranial base (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and the dimension sella\u2010frontale (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.02) were short. (4) The sagittal dimension of the posterior cranial fossa was increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01), and the vertical dimension was reduced (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adults with OI had a hypoplastic, retro\u2010positioned and posteriorly inclined maxilla, a hypoplastic and forward\u2010positioned mandible, and a reduced anterior face height. Deviations were seen in morphology of the posterior cranial fossa. The impact of OI on cranial morphology was generally more evident in OI type III\/IV than in OI type I. OI impacts on osseous cranial structures irrespective of bony origin being intramembranous or endochondral.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12607","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T14:05:10Z","timestamp":1661177110000},"page":"248-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Craniofacial morphology in adults with osteogenesis imperfecta\u2014A cross\u2010sectional study"],"prefix":"10.1111","volume":"26","author":[{"given":"Hans","family":"Gj\u00f8rup","sequence":"first","affiliation":[{"name":"Center for Oral Health in Rare Diseases, Department of Oral and Maxillofacial Surgery Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernille Endrup","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Center for Oral Health in Rare Diseases, Department of Oral and Maxillofacial Surgery Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Dentistry and Oral Health, Faculty of Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannie Dahl","family":"Hald","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Centre for Rare Diseases, Pediatric Department Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte","family":"Haubek","sequence":"additional","affiliation":[{"name":"Department of Dentistry and Oral Health, Faculty of Health Aarhus University  Aarhus 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