{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:15:17Z","timestamp":1754111717962},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Antidepressants, specifically Selective Serotonin Re\u2010uptake Inhibitors (SSRIs), that alter serotonin metabolism are currently the most commonly prescribed drugs for the treatment of depression. There is some evidence to suggest these drugs contribute to birth defects. As jaw development is often altered in craniofacial birth defects, the purpose of this study was to interrogate the effects of in utero SSRI exposure in a preclinical model of mandible development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Wild\u2010type C57BL6 mice were used to produce litters that were exposed in utero to an SSRI, Citalopram (500\u2009\u03bcg\/day). Murine mandibles from P15 pups were analysed for a change in shape and composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis indicated an overall shape change with total mandibular length and ramus height being shorter in exposed pups as compared to controls. Histomorphometric analysis revealed that first molar length was longer in exposed pups while third molar length was shorter in exposed as compared to control. Histological investigation of molars and surrounding periodontium revealed no change in collagen content of the molar in exposed pups, some alteration in collagen composition in the periodontium, increased alkaline phosphatase in molars and periodontium and decreased mesenchymal cell marker presence in exposed mandibles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study reveal SSRI exposure may interrupt mandible growth as well as overall dental maturation in a model of development giving insight into the expectation that children exposed to SSRIs may require orthodontic intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12624","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T14:15:35Z","timestamp":1669990535000},"page":"415-424","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In utero exposure to selective serotonin re\u2010uptake inhibitor affects murine mandibular development"],"prefix":"10.1111","volume":"26","author":[{"given":"Mark A.","family":"Boyce","sequence":"first","affiliation":[{"name":"Department of Biomedical Education &amp; Anatomy The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily L.","family":"Durham","sequence":"additional","affiliation":[{"name":"Department of Anthropology The Pennsylvania State University  State College Pennsylvania USA"},{"name":"Division of Human Genetics, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Anthropology The Pennsylvania State University  State College Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Biomedical Education &amp; Anatomy The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiv","family":"Kishinchand","sequence":"additional","affiliation":[{"name":"Department of Biomedical Education &amp; Anatomy The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda C.","family":"LaRue","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Medical University of South Carolina  Charleston South Carolina USA"},{"name":"Ralph H. Johnson Veterans Administration Medical Center  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Cray","sequence":"additional","affiliation":[{"name":"Department of Biomedical Education &amp; Anatomy The Ohio State University College of Medicine  Columbus Ohio USA"},{"name":"Division of Biosciences The Ohio State University College of Dentistry  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2333"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.632766"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740330802423168"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10673229609030534"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20327"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-397157-9.00024-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2003.00210.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139719"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101528"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3045"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4166"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-010-0026-z"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2018-0085"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2249"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.83a.15066"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-015-0231-5"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.05.003"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15071373"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.9.1.137"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-016-0322-3"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4171-4"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514549378"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117827"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/injuryprev-2014-041483"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23323"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-018-0026-x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-090710-133426"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2140-0"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.72351"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1109\/IEEECONF51394.2020.9443322"},{"key":"e_1_2_10_32_1","volume-title":"RDN_segmentation","author":"Stephens N.","year":"2021"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1109\/VISUAL.2005.1532826"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12810"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-0998.2010.02924.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218376"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096801"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S95470"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61359"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2011.01367.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/166.4.1909"}],"container-title":["Orthodontics &amp; Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.12624","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ocr.12624","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.12624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T18:49:04Z","timestamp":1692298144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ocr.12624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,19]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/ocr.12624"],"URL":"https:\/\/doi.org\/10.1111\/ocr.12624","archive":["Portico"],"relation":{},"ISSN":["1601-6335","1601-6343"],"issn-type":[{"value":"1601-6335","type":"print"},{"value":"1601-6343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,19]]},"assertion":[{"value":"2022-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}