{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:44:25Z","timestamp":1772754265890,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the frequency of molar\u2010incisor hypomineralization (MIH) in individuals born with cleft lip and or cleft palate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings and Sample<\/jats:title><jats:p>Three hundred eighty\u2010six individuals born with cleft lip and\/or palate before orthodontic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All the individuals were submitted to a clinical examination and intraoral standardized photos. The registration of MIH was taken by two orthodontists and analysed in association with the cleft type and laterality. The Kruskal\u2013Wallis test and the regression test were used to compare the frequency of molars and incisors affected according to cleft type and laterality, sex and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a frequency of 67.87% of MIH in the studied sample. The frequency varied from 25% (in individuals born with cleft palate) to 77% in individuals born with bilateral cleft lip and palate). The number of affected molars was statistically different depending on cleft type and laterality (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001\u2010 Kruskal\u2013Wallis test). Differences were found between individuals born with unilateral cleft lip and palate and unilateral cleft lip and alveolus (<jats:italic>P<\/jats:italic>\u2009=\u2009.03), and with isolated cleft palate (<jats:italic>P<\/jats:italic>\u2009=\u2009.03), and between individuals born with bilateral cleft lip and palate and born with unilateral cleft lip and alveolus (<jats:italic>P<\/jats:italic>\u2009=\u2009.01), and cleft palate (<jats:italic>P<\/jats:italic>\u2009=\u2009.01). Sex (<jats:italic>P<\/jats:italic>\u2009=\u2009.21) and age (<jats:italic>P<\/jats:italic>\u2009=\u2009.36) had no influence on the frequency of MIH. A positive correlation was found between the number of molars affected and incisors affected (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Individuals born with cleft lip and palate have a higher frequency of MIH, and the complexity of cleft type was associated with the number of affected molars.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12708","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T15:54:54Z","timestamp":1693324494000},"page":"21-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Molar\u2010incisor hypomineralization in a cohort of individuals born with cleft lip and palate"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-6487","authenticated-orcid":false,"given":"Rosa Helena","family":"Wanderley\u00a0Lacerda","sequence":"first","affiliation":[{"name":"Cleft Lip and Palate Center University Hospital of Paraiba, Federal University of Paraiba  Para\u00edba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7708-6509","authenticated-orcid":false,"given":"Vitor Marques","family":"Filgueiras","sequence":"additional","affiliation":[{"name":"Cleft Lip and Palate Center University Hospital of Paraiba, Federal University of Paraiba  Para\u00edba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Castro","family":"Guedes\u00a0Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Cleft Lip and Palate Center University Hospital of Paraiba, Federal University of Paraiba  Para\u00edba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3392-6881","authenticated-orcid":false,"given":"Alexandre Rezende","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniofacial Sciences, School of Dental Medicine University of Pittsburgh  Pittsburgh Pennsylvania 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