{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:12:03Z","timestamp":1790784723009,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2021\/006208"],"award-info":[{"award-number":["CRG\/2021\/006208"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this systematic review was to compare the effectiveness of pre\u2010alveolar bonegraft (ABG) orthodontics with no orthodontic treatment for patients with non\u2010syndromic unilateral cleft lip, alveolus and palate. All relevant studies from 1946 to October 30, 2022, were identified using several sources including The Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), LILACS, Scopus, EMBASE, MEDLINE (Ovid) and EPUB ahead of publications and non\u2010indexed citations. Randomized Controlled Trials (RCT) and Controlled Clinical Trials (CCT) were included. Population: Non\u2010syndromic complete unilateral cleft lip, alveolus and palate patients who have had ABG surgery. Intervention: Orthodontics prior to ABG. Comparison: No orthodontic treatment prior to ABG. Primary outcome: Successful eruption of permanent canines. All articles were screened for the title, abstract and full text independently and in duplicate by 2 reviewers. The quality assessment of RCT was performed using Cochrane's risk of bias tool and the CCT was assessed using ROBINS\u2010I tool. Of the 904 studies retrieved in the search, one RCT and one CCT were included. Both studies were judged as high risk of bias. The results from one study showed a statistically significant increase in bone volume and decreased bone defect post\u2010ABG in the orthodontic treatment group. However, there was no difference with respect to other variables. Both included studies were of low quality. There is not enough evidence to recommend orthodontic treatment pre\u2010ABG for patients with complete unilateral cleft lip, alveolus and palate. Future high\u2010quality studies are required to inform patients and clinicians about the effectiveness of pre\u2010graft orthodontic treatment.<\/jats:p>","DOI":"10.1111\/ocr.12744","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T14:57:18Z","timestamp":1702911438000},"page":"90-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of pre\u2010alveolar bone graft orthodontics for patients with non\u2010syndromic complete unilateral cleft lip, alveolus and palate: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7809-8111","authenticated-orcid":false,"given":"Badri","family":"Thiruvenkatachari","sequence":"first","affiliation":[{"name":"Sree Balaji Dental College and Hospital Bharath Institute of Higher Education and Research  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhiksha","family":"Chakkaravarthi","sequence":"additional","affiliation":[{"name":"Sree Balaji Dental College and Hospital Bharath Institute of Higher Education and Research  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Prathap","sequence":"additional","affiliation":[{"name":"Sree Balaji Dental College and Hospital Bharath Institute of Higher Education and Research  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niha","family":"Naveed","sequence":"additional","affiliation":[{"name":"Sree Balaji Dental College and Hospital Bharath Institute of Higher Education and Research  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarthi","family":"Bhuvaraghan","sequence":"additional","affiliation":[{"name":"Sree Balaji Dental College and Hospital Bharath Institute of Higher Education and Research  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,18]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","first-page":"216","article-title":"Incidence of cleft lip, cleft palate, and cleft lip and palate among races: a review","volume":"24","author":"Vanderas AP","year":"1987","journal-title":"Cleft Palate J"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0746.110083"},{"issue":"2","key":"e_1_2_12_4_1","first-page":"87","article-title":"Secondary bone grafting of residual alveolar and palatal clefts","volume":"30","author":"Boyne PJ","year":"1972","journal-title":"J Oral Surg"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000008002"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.149293"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12185"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.ED000142"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23597"},{"issue":"6","key":"e_1_2_12_10_1","first-page":"S62","article-title":"Revision rates of alveolar bone grafting in unilateral cleft lip and palate patients with and without orthodontic preparation","volume":"94","author":"Manosudprasit M","year":"2011","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1723070"},{"issue":"3","key":"e_1_2_12_12_1","first-page":"288","article-title":"Effect of alveolar bone grafting on maxillary growth in unilateral cleft lip and palate patients","volume":"25","author":"Semb G","year":"1988","journal-title":"Cleft Palate J"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2019.11.012"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10215143"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.21991"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2018.02.005"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/10556656211002689"},{"issue":"3","key":"e_1_2_12_18_1","first-page":"169","article-title":"The study of presurgical and postsurgical orthodontic treatment of alveolar bone grafting on patients with complete cleft lip and palate","volume":"33","author":"Yan Y","year":"1998","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-021-05505-0"}],"container-title":["Orthodontics &amp; Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.12744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:51:38Z","timestamp":1715529098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ocr.12744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,18]]},"references-count":18,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/ocr.12744"],"URL":"https:\/\/doi.org\/10.1111\/ocr.12744","archive":["Portico"],"relation":{},"ISSN":["1601-6335","1601-6343"],"issn-type":[{"value":"1601-6335","type":"print"},{"value":"1601-6343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,18]]},"assertion":[{"value":"2023-12-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}