{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:46:10Z","timestamp":1782294370362,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the anterior crowding correction after sequential use of the first 5 aligners between two aligner exchange protocols (7 and 14\u2009days) in mature adult patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty\u2010six patients over 35\u2009years who received orthodontic treatment with Invisalign\u00ae were randomly allocated to two different aligner replacement sequence protocols: Group 1: exchange every 7\u2009days (n\u2009=\u200918); and Group 2: exchange every 14\u2009days (n\u2009=\u200918). All patients were scanned with iTero Element 5D\u00ae (Align Technology) in two treatment times: at pre\u2010treatment (T1) and after using the first five aligners (T2). Little's Irregularity Index (LII) and arch widths were evaluated with OrthoCAD software. Intra and intergroup comparisons were performed with the dependent and independent <jats:italic>t<\/jats:italic>\u2010tests. The results were considered significant for <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five patients completed the study. Both groups' maxillary and mandibular Irregularity Indexesi were significantly lower at T2. There was no significant difference in inter\u2010canine, inter\u2010premolar, and intermolar distances.\u00a0G2 (14\u2009days) presented a greater decrease in mandibular irregularity than G1 (7\u2009days).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both exchange protocols (7 and 14\u2009days) effectively correct anterior crowding in the initial phase of orthodontic treatment with aligners in mature adult patients. However, the 14\u2010day exchange protocol provided a greater correction in mandibular anterior crowding in the evaluated period than the 7\u2010day exchange protocol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12766","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T06:45:21Z","timestamp":1707288321000},"page":"544-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of the efficiency of initial dental alignment with Invisalign\u00ae aligners changed every 7 or 14\u2009days in mature adults: Randomized clinical trial"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9706-3125","authenticated-orcid":false,"given":"Tiago","family":"Fialho","sequence":"first","affiliation":[{"name":"Department of Orthodontics Ing\u00e1 University Center \u2010 UNING\u00c1  Maring\u00e1 Paran\u00e1 Brazil"},{"name":"Department of Orthodontics Bauru 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