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Searches were undertaken in PubMed, EMBASE, Web of Science, Cochrane Library, Scopus, and grey literature (Google Scholar and OpenGrey) for eligible cross\u2010sectional observational studies measuring the MRSL and IRCCP in healthy adult patients. The risk of bias and evidence quality were evaluated using the Joanna Briggs Institute's checklist and GRADE framework. Thirteen studies involving 1169 patients were included for qualitative synthesis. Seven of these studies were eligible for quantitative analysis. Meta\u2010analysis showed that the mean MRSL at the subfurcation\u20106\u2009mm plane in Asian normodivergent cases was 3.78\u2009mm (95% confidence interval [CI]: 2.81\u20134.35; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200979.7%) for skeletal Class\u2010I malocclusions, 3.02\u2009mm (95% CI: 2.10\u20133.94; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200962.5%) for Class\u2010II, and 4.43\u2009mm (95% CI: 3.14\u20135.73; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200975.1%) for Class\u2010III. The mean MRSL at the sub\u2010cementoenamel junction (CEJ)\u201010\u2009mm plane for Asian, Class\u2010I, normodivergent cases was 3.28\u2009mm (95% CI: 2.44\u20134.12; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200968.9%). The mean IRCCP for Asian, Class\u2010I, normodivergent cases was 27.2% (95% CI: 0.22\u20130.32; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%). In Asian normodivergent cases, MRSL ranges from 3.28 to 4.43\u2009mm with a 27.2% IRCCP for Class\u2010I. Cone\u2010beam computed tomography imaging is recommended for measuring the MRSL in the apex region particularly before molar distalization. Factors influencing MRSL and IRCCP include different races, skeletal patterns, facial types, and third\u2010molar status.<\/jats:p>","DOI":"10.1111\/ocr.12778","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T06:39:32Z","timestamp":1710139172000},"page":"515-526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Boundary of mandibular molar distalization in orthodontic treatment: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"27","author":[{"given":"Keyuan","family":"Liu","sequence":"first","affiliation":[{"name":"Orthodontics, Division of Paediatric Dentistry and Orthodontics, Faculty of Dentistry The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Chu","sequence":"additional","affiliation":[{"name":"Orthodontics, Division of Paediatric Dentistry and Orthodontics, Faculty 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