{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:45:43Z","timestamp":1780109143871,"version":"3.54.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the association between third molar agenesis and supernumerary tooth formation in a white\u2010European population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A record review in various orthodontic clinics identified 380 eligible white\u2010European individuals, half of whom had non\u2010syndromic permanent supernumerary teeth (122 males and 68 females, totalling 244 supernumerary teeth; median age: 13.1, iqr: 1.5\u2009years), and the other half were age\u2010 and sex\u2010matched controls with full dentition, excluding the third molars. Tooth sequences were identified in panoramic radiographs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the supernumerary group, approximately 80% of the individuals had a single supernumerary tooth, followed by those having two additional teeth. In both groups, there was no sexual dimorphism in third molar agenesis severity. The prevalence of third molar agenesis in the supernumerary group was similar to that of the control group (28\/190\u2009=\u200914.7% in both groups; <jats:italic>p<\/jats:italic>\u2009=\u20091.0). In total, 53 third molars were missing in the supernumerary group (n\u2009=\u2009190) compared to 67 in the control group (n\u2009=\u2009190; <jats:italic>p<\/jats:italic>\u2009=\u2009.862). The ratio of bilateral to unilateral third molar agenesis was significantly lower in the supernumerary group than in the control group (1.0 vs. 3.7, respectively; <jats:italic>p<\/jats:italic>\u2009=\u2009.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of supernumerary teeth did not significantly alter the likelihood of third molar agenesis or its severity. Bilateral third molar agenesis was considerably less prevalent in individuals with supernumerary teeth compared to controls. The present novel findings have important clinical and developmental implications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12807","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T11:38:35Z","timestamp":1715254715000},"page":"795-802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Third molar agenesis in individuals with supernumerary teeth"],"prefix":"10.1111","volume":"27","author":[{"given":"Luca","family":"Friedli","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Henninger","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miltiadis A","family":"Makrygiannakis","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios F","family":"Zymperdikas","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, School of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moschos A","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, School of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Kanavakis","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"},{"name":"Department of Orthodontics and Pediatric Dentistry UZB \u2013 University School of Dental Medicine, University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-6272","authenticated-orcid":false,"given":"Nikolaos","family":"Gkantidis","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine University of Bern  Bern 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