{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:41:55Z","timestamp":1770702115687,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to establish a fully digital measurement protocol for standardizing the description of hard palate and cleft morphology in neonates with an isolated cleft palate (CPO) and Pierre Robin sequence (PRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 20 digitized plaster models of neonates with CPO and 20 digitized plaster models of neonates with PRS were retrospectively investigated. For the control group, the hard palate was segmented from 21 pre\u2010existing 1.5\u2009T MRI datasets of neonates and exported as an STL file. The digital models were marked with predefined reference points by three raters. Distance, angular, and area measurements were performed using Blender and MeshLab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neonates with CPO (20.20\u2009\u00b1\u20092.33\u2009mm) and PRS (21.41\u2009\u00b1\u20091.81\u2009mm) had a significantly shorter hard palate than the control group (23.44\u2009\u00b1\u20092.24\u2009mm) (CPO vs. control: <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001; PRS vs. control: <jats:italic>P<\/jats:italic>\u2009=\u2009.014). Notably, neonates with PRS (33.05\u2009\u00b1\u20091.95\u2009mm) demonstrated a significantly wider intertuberosity distance than those with CPO (30.52\u2009\u00b1\u20092.28\u2009mm) (<jats:italic>P<\/jats:italic>\u2009=\u2009.012). Furthermore, there were also significant differences measured between the cleft and control groups (25.22\u2009\u00b1\u20092.50\u2009mm) (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The data from this study demonstrate the feasibility of using MRI datasets to generate digital models of the hard palate. The presence of a cleft palate leads to pronounced adaptations of the total palatal surface area, dorsal width, and length of the hard palate. Mandibular retrognathia and altered tongue position in PRS, as opposed to CPO, might further impact palatal morphology and intertuberosity distance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12818","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T06:50:39Z","timestamp":1716533439000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of hard palate and cleft morphology in neonates with Pierre Robin Sequence and Cleft Palate Only"],"prefix":"10.1111","volume":"27","author":[{"given":"Ines","family":"Willershausen","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Orofacial Orthopedics Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Krautkremer","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Medicine Technische Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Str\u00f6bel","sequence":"additional","affiliation":[{"name":"Center for Clinical Studies (CCS) Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Abu\u2010Tair","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Institute of Functional and Clinical Anatomy Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg  Erlangen 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