{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:06:09Z","timestamp":1768557969916,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to investigate whether cumulative dose\u2010dependent isotretinoin (Roaccutane\u00ae) could affect orthodontic tooth movement (OTM) and root resorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Ninety male Wistar Albino rats were divided into 4 groups. While, the control (SALINE), solvent (SOYBEAN) and orthodontic drug (ISOTM) groups underwent orthodontic force, the non\u2010orthodontic drug group (ISO) did not. The rats were administrated saline, soybean oil (SBO) and isotretinoin diluted in SBO (ISOTM, ISO) for 30\u2009days, respectively. Six rats were euthanized in each orthodontic group. Fifty grams of orthodontic force was applied to the remaining rats' first molars using the incisors as anchorage. Six more rats in each group were euthanized on the 7th, 14th and 21st days of the force application. In the ISO group, six rats were euthanized on the 37th, 44th and 51st days of administration. Six rats that were euthanized for ISOTM on the 30th day were also used for ISO to reduce the number of rats used. Micro\u2010computed tomography (micro\u2010CT) and histological analysis were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Independent of orthodontic force, isotretinoin caused root resorption in the apical region. However, there was no statistically significant influence of isotretinoin on OTM and orthodontically induced root resorption (OIRR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the lack of strong evidence supporting the orthodontically induced resorptive effect of isotretinoin, this study provided findings regarding the resorptive effects of isotretinoin on non\u2010orthodontic root resorption. Therefore, the present results underscore the importance of close monitoring during orthodontic treatment to mitigate potential root resorption in patients who use isotretinoin because of acne complaints.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12840","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T17:25:06Z","timestamp":1723483506000},"page":"974-984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of isotretinoin on tooth movement, orthodontically induced and non\u2010orthodontic root resorption: A micro\u2010CT study"],"prefix":"10.1111","volume":"27","author":[{"given":"Gulay Dumanli","family":"Gok","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry Abant Izzet Baysal University  Bolu Turkey"},{"name":"Department of Orthodontics, Faculty of Dentistry Biruni University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koray","family":"Halicioglu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry Abant Izzet Baysal University  Bolu Turkey"},{"name":"Department of Orthodontics, Faculty of Dentistry Biruni University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Keles","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry Ondokuz May\u0131s University  Samsun Turkey"},{"name":"Department of Endodontics, Faculty of Dentistry Abant Izzet Baysal University  Bolu Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nejat Vakur","family":"Olgac","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damla","family":"Kayali","sequence":"additional","affiliation":[{"name":"Department of Histology and Embriology, Basic Medical Sciences Marmara School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2591-9174","authenticated-orcid":false,"given":"Ozlem Tugce Cilingir","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Histology and Embriology, Basic Medical Sciences Marmara School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/EJO\/CJAA058"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516677539"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0151-x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1057"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113721"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/116.4.578"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03340140069034"},{"key":"e_1_2_11_9_1","first-page":"368","volume-title":"Nutritional Aspects of Bone Health","author":"Melhus H","year":"2003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.03.025"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.04.032"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.11.006"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10370"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2019.0108"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2010.03.009"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-010-0235-8"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12151"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3305\/nh.2015.31.5.8231"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071668.2014.949624"},{"key":"e_1_2_11_20_1","unstructured":"Gulay Dumanli Gok.Ulusal Tez Merkezi | Anasayfa.2017Available from:https:\/\/tez.yok.gov.tr\/UlusalTezMerkezi\/tezSorguSonucYeni.jsp. 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