{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:54:34Z","timestamp":1787165674543,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The effects of unilateral increased occlusal vertical dimension (iOVD) on bilateral craniofacial, mandibular and alveolar development in growing rats were investigated via cone\u2010beam computed tomography (CBCT). The role of Wnt\/\u03b2\u2010catenin signalling in this process was examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Forty\u2010eight female Sprague\u2013Dawley rats were randomly allocated into unilateral iOVD and sham groups. At 2, 4 and 8\u2009weeks, the rats were scanned via CBCT to analyse cranial, maxillary, mandibular and dental morphology. Changes in temporomandibular joint (TMJ) cartilage histology and Wnt\/\u03b2\u2010catenin signalling were assessed by histochemical and immunohistochemical staining and qRT\u2013PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dorsal cephalograms revealed that the mandible in the iOVD group tilted approximately 4\u00b0 to the right. Unilateral iOVD had little effect on cranial and maxillary growth but inhibited mandibular growth (mandibular length and ramal height), especially on the deviated side (DS). Moreover, unilateral iOVD increased the length of the lower incisors and decreased the height of the molars on the DS. Unilateral iOVD induced bilateral osteoarthritis\u2010like changes in the bilateral TMJ condylar cartilage and activated Wnt\/\u03b2\u2010catenin signalling in the condylar cartilage, especially on the contralateral side (CLS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Occlusion with unilateral iOVD induced mandibular deviation, significantly inhibited mandibular growth and produced compensatory changes in the alveolar bone. In the iOVD group, the mandibular body length and ramal height were greater on the CLS than on the DS. Moreover, the greater \u03b2\u2010catenin protein expression in the TMJ condylar cartilage on the CLS than on the DS may account for the difference in asymmetrical mandibular development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ocr.12851","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T04:09:16Z","timestamp":1724818156000},"page":"84-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A unilateral increase in the occlusal vertical dimension of growing rats results in mandibular deviation"],"prefix":"10.1111","volume":"28","author":[{"given":"Senxin","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Fujian Medical University  Fuzhou China"},{"name":"Key Laboratory of Stomatology of Fujian Province, School and Hospital of Stomatology Fujian Medical University  Fuzhou 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