{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:46:26Z","timestamp":1790178386251,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A \u201cspontaneous\u201d correction of the Class II malocclusion has been described after maxillary expansion (ME) treatment. The aim of the present review was to systematically summarize changes in the sagittal dentoskeletal parameters of growing Class II patients after ME. The study protocol was developed according to the PRISMA statement and registered in PROSPERO before literature search, data extraction and analysis. The PICO model was followed in the definition of the research question, search strategies and study selection criteria. Randomized and non\u2010randomized studies on the sagittal effects of ME published in English language without date restrictions were electronically searched across the Cochrane Library, Scopus and MEDLINE\/PubMed databases. Changes in sagittal dentoskeletal cephalometric parameters were analysed. The risk of bias in randomized and nonrandomized studies was assessed using the Rob2 and ROBINS\u2010I tools, respectively. A narrative synthesis was performed, focusing on the investigated population, intervention, comparison, and main outcomes. Pairwise meta\u2010analyses were used to compare the outcomes assessed in subjects who underwent ME versus untreated subjects. Ten studies met the inclusion criteria, four were included in the pairwise meta\u2010analyses due to the presence of a control group. Slight but significant improvements in OVJ (MD: \u22120.36; 95%; CI [\u22120.69 to \u22120.01]; <jats:italic>p<\/jats:italic>\u2009=\u2009.04) and 6\/6 molar relation (MD: 1.5; 95%; CI [0.69 to 1.61]; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) were found in patients who underwent ME compared with untreated subjects, whereas no improvement in skeletal parameters was observed. However, the limitations of a small body of moderate\u2010quality evidence and possible confounding factors should be considered. Evidence on the sagittal skeletal and dental effects of ME in Class II patients is still ambiguous, suggesting the need for more clinical trials, including appropriate control subjects, randomization and blinding during outcome assessment.<\/jats:p>","DOI":"10.1111\/ocr.12852","type":"journal-article","created":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T08:04:32Z","timestamp":1725782672000},"page":"116-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of maxillary expansion on the sagittal skeletal and dental parameters of growing Class II patients: A systematic review with meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"Davide","family":"Cannat\u00e0","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d University of Salerno  Baronissi 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Surgery and Dentistry \u201cScuola Medica Salernitana\u201d University of Salerno  Baronissi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3877-1671","authenticated-orcid":false,"given":"Stefano","family":"Martina","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d University of Salerno  Baronissi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,8]]},"reference":[{"issue":"3","key":"e_1_2_14_2_1","first-page":"177","article-title":"Components of class II malocclusion in children 8\u201310\u2009years of age","volume":"51","author":"McNamara JA","year":"1981","journal-title":"Angle 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