{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T15:36:16Z","timestamp":1792337776841,"version":"4.4.0"},"reference-count":70,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Palatal impaction of the maxillary canine is commonly considered as a genetic condition, while the lateral incisor root has been suggested to guide maxillary permanent canine eruption. This review assessed whether agenesis of the maxillary lateral incisor is associated with eruption disturbances of the maxillary canine (displacement or impaction). Unrestricted searches in six databases for observational case\u2013control human studies until May 2024 assessing eruption disturbances of the permanent maxillary canine in conjunction with permanent maxillary lateral incisor agenesis were performed. Study selection, data extraction and risk\u2010of\u2010bias assessment with the Joanna Briggs Institute's tool were performed in duplicate. Random\u2010effects meta\u2010analyses of odds ratios (ORs) with their 95% confidence intervals (CIs) were performed, followed by meta\u2010regressions and sensitivity analyses. Seventeen reports pertaining to 17 case\u2013control studies were included covering 10,155 patients (11.6\u2009year\u2010old\/46% male on average). Maxillary lateral incisor agenesis was associated with eruption disturbance of the maxillary canine (17\u2009studies; OR\u2009=\u20093.88; 95% CI\u2009=\u20092.05\u20137.34; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; <jats:italic>I<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u200958). Lateral incisor agenesis was more associated with canine displacement (7 studies; OR\u2009=\u20097.56; 95% CI\u2009=\u20092.10\u201327.18; <jats:italic>p<\/jats:italic>\u2009=\u20090.008; <jats:italic>I<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u200957) and to a lesser degree with canine impaction (10\u2009studies; OR\u2009=\u20092.39; 95% CI\u2009=\u20091.28\u20134.48; <jats:italic>p<\/jats:italic>\u2009=\u20090.01). No significant effects of patient age or sex were seen, and the results were robust to study design and precision. The quality of evidence was low due to the inclusion of observational case\u2013control studies with methodological issues and residual confounding. Evidence indicates that permanent maxillary lateral incisor agenesis is associated with eruption disturbances of the permanent maxillary canine, including mainly displacement, but also impaction.<\/jats:p><jats:p>\n<jats:bold>Trial Registration:<\/jats:bold> PROSPERO database number: CRD42024549898<\/jats:p>","DOI":"10.1111\/ocr.12878","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T09:58:28Z","timestamp":1732355908000},"page":"312-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Does Current Evidence Support the Discussion Around the Guidance Theory? A Systematic Review and Meta\u2010Analysis on the Association Between Maxillary Lateral Incisor Agenesis and Displacement or Impaction of the Permanent Canine"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1968-3326","authenticated-orcid":false,"given":"Spyridon N.","family":"Papageorgiou","sequence":"first","affiliation":[{"name":"Clinic of Orthodontics and Pediatric Dentistry, Center for Dental Medicine University of Zurich  Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3243-1580","authenticated-orcid":false,"given":"Jadbinder","family":"Seehra","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, Oral &amp; Craniofacial Sciences King's College London  London UK"},{"name":"Centre for Craniofacial Development and Regeneration, Faculty of Dentistry, Oral &amp; Craniofacial Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2857-0315","authenticated-orcid":false,"given":"Martyn T.","family":"Cobourne","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, Oral &amp; Craniofacial Sciences King's College London  London UK"},{"name":"Centre for Craniofacial Development and Regeneration, Faculty of Dentistry, Oral &amp; Craniofacial Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-044X","authenticated-orcid":false,"given":"Georgios","family":"Kanavakis","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"},{"name":"Department of Orthodontics and Pediatric Dentistry, UZB\u2014University School of Dental Medicine University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2021.1936163"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(87)90005-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(92)70008-X"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4807250"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjx047"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2020.12.019"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12423"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2319\/042122-304.1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-04662-3"},{"key":"e_1_2_12_11_1","first-page":"249","article-title":"The Palatally Displaced Canine as a Dental Anomaly of Genetic Origin","volume":"64","author":"Peck S.","year":"1994","journal-title":"Angle Orthodontist"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2015.06.013"},{"key":"e_1_2_12_13_1","first-page":"95","article-title":"In Defense of the Guidance Theory of Palatal Canine Displacement","volume":"65","author":"Becker A.","year":"1995","journal-title":"Angle Orthodontist"},{"key":"e_1_2_12_14_1","first-page":"99","article-title":"Sense and Nonsense Regarding Palatal Canines","volume":"65","author":"Peck S.","year":"1995","journal-title":"Angle Orthodontist"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514523986"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700606"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1465312518820537"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17147.1"},{"key":"e_1_2_12_19_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins J. 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