{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:12:13Z","timestamp":1757542333291,"version":"3.38.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008386","name":"Marmara \u00dcniversitesi","doi-asserted-by":"publisher","award":["TDH\u20102022\u201010484"],"award-info":[{"award-number":["TDH\u20102022\u201010484"]}],"id":[{"id":"10.13039\/501100008386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to examine whether <jats:italic>ACTN3<\/jats:italic> rs1815739 polymorphism, which causes the deficiency of the alpha\u2010actinin\u20103 muscle protein, is related to the formation of open bite malocclusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fifty\u2010eight participants (18.5\u2009\u00b1\u20093.6\u2009years old) with anterior open bite (<jats:italic>n<\/jats:italic>\u2009=\u200929) and normal overbite (<jats:italic>n<\/jats:italic>\u2009=\u200929) who presented to Marmara University, Department of Orthodontics for treatment were included in the study. Initial cephalometric radiographs were used for the diagnosis of malocclusion. The case group was divided into three subgroups according to degree of open bite. For DNA isolation, oral epithelial cells were collected with buccal swabs (Van Allen Way, Carlsbad, USA), and the real\u2010time PCR method was used for the genotyping of all polymorphisms. The results were statistically analysed, and the threshold for statistical significance was set at <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequencies of RR, RX and XX genotypes of <jats:italic>ACTN3<\/jats:italic> rs1815739 polymorphism were found as 6 (20.7%), 14 (48.3%) and 9 (31.0%) in the control group and 8 (8%), 9 (31.0%) and 12 (41.4%) in the case group, respectively. There was no statistically significant difference between the groups in terms of the presence of the examined polymorphism (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). However, the intra\u2010group evaluation of case group revealed a significant difference in the prevalence of XX genotype (83.3%) for the subgroup with an open bite of \u22125\u2009mm or above.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although no significant difference was observed between the case and control groups, a possible association was identified between <jats:italic>ACTN3<\/jats:italic> rs1815739 polymorphism and an increased severity of open bite malocclusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ocr.12886","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T12:30:51Z","timestamp":1734525051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of the Relationship Between <scp>ACTN3<\/scp> rs1815739 Polymorphism and Openbite Cases: A Prospective Study"],"prefix":"10.1111","author":[{"given":"Elif Asl\u0131han","family":"Yaylac\u0131","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry Marmara University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-2320","authenticated-orcid":false,"given":"Elvan","family":"Onem Ozbilen","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry Marmara University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beste Tacal","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Dentistry Marmara University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolga","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Dentistry Marmara University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(64)90175-7"},{"key":"e_1_2_11_3_1","first-page":"420","article-title":"Ricketts on Growth Prediction","volume":"9","author":"Brandt S.","year":"1975","journal-title":"Journal of Clinical Orthodontics"},{"key":"e_1_2_11_4_1","first-page":"247","article-title":"Vertical Malocclusions: Etiology, Development, Diagnosis and Some Aspects of Treatment","volume":"61","author":"Nielsen I. 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