{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:59:39Z","timestamp":1787504379330,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2018Y00162"],"award-info":[{"award-number":["2018Y00162"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Different protocols exist regarding wear time of invisible aligners. There is no study that compared the effect of different protocols. The aim of this study was to assess the effect of Invisalign aligners in four first\u2010premolar extraction treatments in adolescents using three aligner wear protocols, every 7, 10 and 14\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In the experimental set\u2010up, 50 participants were divided into three distinct groups: group A, with a regimen of changing aligners every 7\u2009days; group B, with a 10\u2010day interval for aligner replacement; and group C, where aligners were replaced every 14\u2009days. The evaluation of occlusal adjustments was conducted employing the Discrepancy Index (DI) and the Cast\u2010Radiograph Evaluation (CRE), as defined by the American Board of Orthodontics for the purpose of recording orthodontic outcomes. The treatment duration, number of maxillary and mandibular Invisalign aligners, and number of Invisalign restarts were\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/fanyi.baidu.com\/mtpe-individual\/multimodal?ext_channel=Aldtype\">simultaneously<\/jats:ext-link>\n                      recorded and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/fanyi.baidu.com\/mtpe-individual\/multimodal?ext_channel=Aldtype\">evaluated<\/jats:ext-link>\n                      . The data set was statistically examined using ANOVA, complemented by the\n                      <jats:italic>F<\/jats:italic>\n                      \u2010test, least significant difference (LSD) method and Tamhane's T2 test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The final sample size for analysis is 45 cases, with five cases lost to follow\u2010up. Before treatment, the three groups showed no significant difference in the degree of malocclusion or each item of DI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Posttreatment, within groups, and regardless of the wearing protocol, the total CRE scores demonstrated no statistically significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). For the other items, groups A and C completed occlusal relations and interproximal contacts significantly better than did group B (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The group C cases had the least number of Invisalign refinement (3.93\u2009\u00b1\u20090.96 vs. 4.93\u2009\u00b1\u20090.70 vs. 6.00\u2009\u00b1\u20091.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), but the treatment duration and number of Invisalign aligners were not significantly different (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The different treatment timing protocols showed equivalent effectiveness regarding treatment outcome, with significantly improved results for the 7\u2010 and 14\u2010day protocol in terms of occlusal relations and interproximal contacts. The attainment of comparable clinical accuracy between the 7\u2010 and 14\u2010day protocol, within a treatment duration of fewer than 3\u2009months, indicates that the 7\u2010day protocol can be deemed an effective treatment approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ocr.12898","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T06:10:05Z","timestamp":1736316605000},"page":"466-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of Invisalign Wear Protocol on the Efficacy of Tooth Movement in Four First\u2010Premolar Extraction in Adolescent Patients: A Randomised Controlled Trial"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8968-5612","authenticated-orcid":false,"given":"YaoHui","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Oral Prevention, School and Hospital of Stomatology Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","unstructured":"M.Tindera \u201cBracing for Competition? Cheaper Challengers Enter Invisalign's $1.5 Billion Market \u201dForbes (2018) accessed January 15 2020 https:\/\/www.forbes.com\/sites\/michelatindera\/2018\/05\/02\/bracing\u2010for\u2010competition\u2010cheaper\u2010challengers\u2010enterinvisaligns\u20101\u20105\u2010billion\u2010market\/#1fb9cbf92392.","DOI":"10.1016\/S1350-4789(18)30076-X"},{"key":"e_1_2_12_3_1","first-page":"24","article-title":"A Three\u2010Dimensional Finite Element Analysis of Upper\u2010Canine Distalization With Clear Aligners, Composite Attachments, and Class II Elastics","volume":"51","author":"Comba B.","year":"2017","journal-title":"Journal of Clinical Orthodontics"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12353"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjz094"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sodo.2016.10.008"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000005572"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2319\/022717\u2010147.1"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2019.12.015"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2319\/100106\u2010398.1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2016.06.041"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12353"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2319\/122919\u2010844.1"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2319\/020923\u201094.1"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2319\/032921\u2010246.1"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.38311"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ortho.2023.100817"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.30147"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.25472"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/jos.jos_30_23"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010020\u201001300\u20106"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.2319\/090418\u2010646.1"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40510\u2010022\u201000447\u2010y"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2023.10.014"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1067\/j.ajodo.2003.08.001"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.2319\/071520\u2010630.1"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0889\u20105406(03)00576\u20106"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12842"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2024.06.014"},{"key":"e_1_2_12_30_1","unstructured":"American Board of Orthodontics \u201cDownloads and Resources \u201daccessed August 13 2022 https:\/\/www.americanboardortho.com\/orthodontists\/board\u2010certified\u2010orthodontistsupport\/downloads\u2010and\u2010resources\/."},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010024\u201004099\u20108"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/eea.12090"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200109"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510377791"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1179\/1465313315Y.0000000004"}],"container-title":["Orthodontics &amp; 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