{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:30:23Z","timestamp":1785547823858,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009238","name":"Virginia Commonwealth University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Integrating artificial intelligence (AI) and advanced three\u2010dimensional (3D) imaging has revolutionised dentistry by enhancing diagnostics and treatment planning. Advanced algorithms and machine\u2010learning techniques may enable orthodontists to analyse complex cases and predict treatment outcomes accurately. This technology facilitates the creation of customised treatment plans that consider individual tooth morphology and periodontal health, optimising force application and minimising treatment time. Since their introduction, clear aligners have gained popularity, with over 17 million people treated by 2023. Compared with fixed appliances, clear aligners offer advantages, such as better aesthetics, comfort and oral hygiene. Treating patients with a compromised periodontium requires accurate diagnosis and treatment planning. This paper reviews how AI\u2010driven treatment planning software predicting root movement and visualising bone structures may impact treatment decisions and, ultimately, treatment outcomes. The technology behind machine learning and AI in designing clear aligners is discussed. Research shows that when viewing the cases in 3D, clinicians are more comfortable when treating crowding cases with a non\u2010extraction approach using interproximal reduction (IPR) only. However, it was interesting to note that clinicians with extensive experience treating clear aligner patients were more comfortable using IPR to address severe crowding cases when viewed in 2D, compared with those less experienced with clear aligners. However, when the cases were visualised in 3D, both groups showed equal comfort in using IPR, as the roots were within the bone. AI\u2010driven treatment planning software, utilising machine learning in conjunction with 3D modelling, may enhance the predictability of orthodontic movements while reducing treatment time and increasing patient satisfaction.<\/jats:p>","DOI":"10.1111\/ocr.12921","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T14:24:34Z","timestamp":1742826274000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["How\n                    <scp>AI<\/scp>\n                    \u2010Driven Root and Bone Predictions Can Assist Clear Aligner Treatment Planning"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9379-7316","authenticated-orcid":false,"given":"Eser","family":"T\u00fcfek\u00e7i","sequence":"first","affiliation":[{"name":"Department of Orthodontics Virginia Commonwealth University, School of Dentistry  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline K.","family":"Carrico","sequence":"additional","affiliation":[{"name":"Department of Dental Public Health and Policy Virginia Commonwealth University, School of Dentistry  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina B.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Virginia Commonwealth University, School of Dentistry  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Lindauer","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Virginia Commonwealth University, School of Dentistry  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2015.09.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2021.02.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/115083"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40510\u2010021\u201000361\u20109"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12543"},{"key":"e_1_2_8_7_1","unstructured":"American Dental Association Standards Committee on Dental Informatics White Paper No. 1106 for Dentistry \u201cOverview of Artificial and Augmented Intelligence Uses in Dentistry \u201d2022 https:\/\/www.ada.org\/\u2010\/media\/project\/ada\u2010organization\/ada\/ada\u2010org\/files\/resources\/practice\/dental\u2010standards\/ada_1106_2022.pdf\/."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2015.45.6.193"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12177"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/jos.jos_170_21"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010023\u201003257\u20108"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2319\/073118\u2010553.1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010021\u201001474\u20107"},{"key":"e_1_2_8_14_1","unstructured":"\u201cClear Aligner Therapy: The Discreet Way to Straighten Teeth \u201dhttps:\/\/aaoinfo.org\/whats\u2010trending\/clear\u2010aligner\u2010therapy\/."},{"key":"e_1_2_8_15_1","unstructured":"\u201cClear Aligners Market Size Share & Trends Analysis Report by Age (Adults Teens) by Material by End\u2010use (Hospitals Standalone Practices) by Distribution Channel and Regional Forecasts 2024\u20132030 \u201dhttps:\/\/www.grandviewresearch.com\/industry\u2010analysis\/clear\u2010aligners\u2010market\/."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdmed.2024.1353114"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2319\/102716\u2010774.1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.16\u20100581"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2319\/040811\u2010250.1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14539"},{"key":"e_1_2_8_21_1","unstructured":"3D Predict uses AI to accelerate orthodontic treatments \u201cGoogle Cloud Blog 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