{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:54:46Z","timestamp":1773273286025,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08DE031347"],"award-info":[{"award-number":["K08DE031347"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005648","name":"American Association of Orthodontists Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Temporomandibular joint osteoarthritis is a degenerative disease with a higher prevalence in women, yet its sex\u2010specific mechanisms remain unclear. This study investigates fibrocartilage degradation in a burn\u2010synovectomy TMJ OA mouse model, hypothesizing that female mice exhibit greater cartilage degradation due to differential inflammatory responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PRG4\u2010CreERT2; Ai9 mice (12\u2010week\u2010old males and females) underwent burn\u2010synovectomy injuries and were euthanized at 1, 3, and 9\u2009weeks for histological and immunofluorescence analyses. PRG4 and MMP\u201013 expression were assessed to evaluate fibrocartilage integrity and degradation. Statistical significance was determined using ANOVA and post hoc testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Female mice showed significantly higher Osteoarthritis Research Society International (OARSI) scores and MMP\u201013\/PRG4 ratios at later time points, indicating sustained degradation. PRG4 expression increased similarly in both sexes in all time points, but MMP\u201013 expression was significantly higher in females at 9\u2009weeks, suggesting heightened cartilage catabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights sex\u2010based differences in TMJ OA progression, reinforcing the importance of targeted therapeutic strategies. The burn\u2010synovectomy model effectively replicates TMJ OA pathology, making it a valuable tool for future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ocr.12946","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T03:29:34Z","timestamp":1748662174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of Differential Fibrocartilage Degradation Between Sexes in a Burn\u2010Synovectomy Temporomandibular Osteoarthritis Mouse Model"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0090-3141","authenticated-orcid":false,"given":"Amy Z.","family":"Lu","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5239-082X","authenticated-orcid":false,"given":"Jeffrey","family":"Nickel","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Craniofacial Sciences Oregon Health and Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-3413","authenticated-orcid":false,"given":"Ginny Ching\u2010Yun","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Craniofacial Sciences Oregon Health and Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.01.014"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100722.2002.11212.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400420"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2007.02.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.4474"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157876"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14030219"},{"key":"e_1_2_10_9_1","first-page":"67","article-title":"TMD Treatment Need in Relation to Age, Gender, Stress, and Diagnostic Subgroup","volume":"12","author":"Kuttila M.","year":"1998","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.08.07.552340"},{"key":"e_1_2_10_11_1","article-title":"Burn\u2010Induced Bone Loss: Importance, Mechanisms, and Management","volume":"5","author":"Klein G. 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