{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T08:38:28Z","timestamp":1762850308354,"version":"build-2065373602"},"reference-count":80,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To perform a quantitative assessment and best\u2010evidence synthesis of maxillary protraction techniques for unilateral cleft lip, alveolus, and palate (UCLAP), incorporating all available studies regardless of methodological quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Studies on growing non\u2010syndromic UCLAP patients requiring maxillary protraction\u2014against treated or untreated comparator groups\u2014were identified across databases including PubMed, Embase, Scopus, Web of Science, EBSCOhost, Ovid MEDLINE, LILACS, Cochrane Library, and grey literature until April 23, 2025. Risk of bias for included studies was assessed using the Methodological Index for Non\u2010randomised Studies and the Cochrane Risk of Bias tool. A random effects model was applied using RevMan for quantitative analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The search identified 1,892 articles, of which 36 met the inclusion criteria, categorised under four protraction methods: bone\u2010anchored, skeletally\u2010anchored facemask, facemask (FM) only, and intraoral springs, with or without expansion. Quantitative synthesis was feasible only for the FM group. Compared to no\u2010protraction UCLAP (NP\u2010UCLAP), Protraction group (P\u2010UCLAP) showed a significant short\u2010term increase in ANB angle (MD\u2009=\u20094.34; 95% CI: 3.65\u20135.03;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200973%). When compared to treated non\u2010cleft individuals, FM therapy also showed a significant ANB increase (MD\u2009=\u20090.86; 95% CI: 0.42\u20131.29;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001;\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20094.65;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200935%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FM therapy shows short\u2010term benefits from low\u2010quality studies for UCLAP maxillofacial growth and future studies might not be necessary as supported by sequential analysis. Evidence for skeletally anchored methods and addition of expansion to any protraction method remains weak and rigorous, long\u2010term studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ocr.70014","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T11:10:16Z","timestamp":1754651416000},"page":"885-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Maxillary Protraction Techniques on Maxillofacial, Dental, and Soft Tissue Outcomes in Patients With Non\u2010Syndromic Unilateral Cleft Lip and Palate: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-4993","authenticated-orcid":false,"given":"Hamza Parvez","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, Sir John Walsh Research Institute University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8172-0090","authenticated-orcid":false,"given":"Anne Marie","family":"Kuijpers\u2010Jagtman","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Medical Center Groningen, University of Groningen  Groningen the Netherlands"},{"name":"Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine\/Medical Faculty University of Bern  Bern Switzerland"},{"name":"Department of Orthodontics, Faculty of Dentistry Universitas Gadjah Mada  Yogyakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-3691","authenticated-orcid":false,"given":"Karthik","family":"Sennimalai","sequence":"additional","affiliation":[{"name":"Department of Orthodontics All India Institute of Medical Sciences Vijaypur  Jammu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Meazzini","sequence":"additional","affiliation":[{"name":"Department of Maxillo\u2010Facial Surgery, Smile House, Regional Center for CLP San Paolo e Carlo Hospital, University of Milano  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2150-6022","authenticated-orcid":false,"given":"Madhanraj","family":"Selvaraj","sequence":"additional","affiliation":[{"name":"Consultant Orthodontist  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitender","family":"Machawal","sequence":"additional","affiliation":[{"name":"Central Hospital  Asansol India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008050.pub2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)60695\u20104"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"issue":"5","key":"e_1_2_11_5_1","first-page":"331","article-title":"An Update on the Aetiology of Orofacial Clefts","volume":"10","author":"Wong F. 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