{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T11:58:31Z","timestamp":1769255911789,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009968","name":"Tiroler Wissenschaftsf\u00f6rderung","doi-asserted-by":"publisher","award":["F.45069\/8\u20102022"],"award-info":[{"award-number":["F.45069\/8\u20102022"]}],"id":[{"id":"10.13039\/501100009968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The NLRP3 inflammasome is a damage sensor driving pyroptotic cell death during orthodontic tooth movement (OTM). Recent studies have revealed impaired one\u2010week OTM in mice lacking NLRP3. However, the relevance of NLRP3 during long\u2010term OTM remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      OTM was analysed after 7, 14 and 21\u2009days of force application in mice lacking NLRP3 (NLRP3\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      ), wild\u2010type (WT) male and female littermates. Micro\u2010computed tomography (\u03bcCT) was used to assess molar movement and bone quality. Tartrate\u2010resistant acid phosphatase (TRAP) staining was used to visualise osteoclastic activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We show here that after 2\u2009weeks of force application, OTM was delayed in mice lacking NLRP3 compared to WT mice. Interestingly, OTM regained speed in NLRP3\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice catching up with the WT controls at day 21. Independent of NLRP3 expression, OTM caused alveolar bone loss compared to the untreated contralateral side. NLRP3\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice showed a diminished number of TRAP\u2010positive osteoclasts than WT male mice 14 and 21\u2009days after OTM induction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this study suggest that NLRP3 is relevant during the early but not later stages of OTM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ocr.70059","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T11:38:56Z","timestamp":1762947536000},"page":"134-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The\n                    <scp>NLRP3<\/scp>\n                    Inflammasome Regulates Orthodontic Tooth Movement"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7523-0268","authenticated-orcid":false,"given":"Lisa","family":"Latzko","sequence":"first","affiliation":[{"name":"University Hospital for Orthodontics, Department of Dental and Oral Medicine and Cranio\u2010Maxillofacial and Oral Surgery Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Degenhart","sequence":"additional","affiliation":[{"name":"Department of Radiology, Core Facility MicroCT Medical University Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Blumer","sequence":"additional","affiliation":[{"name":"Institute of Clinical and Functional Anatomy Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-9009","authenticated-orcid":false,"given":"Reinhard","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Hayb\u00e4ck","sequence":"additional","affiliation":[{"name":"Tyrolpath Obrist Brunhuber GmbH  Zams Austria"},{"name":"Diagnostic and Research Institute of Pathology Diagnostic and Research Center of Molecular BioMedicine, Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Manzl","sequence":"additional","affiliation":[{"name":"Institute of Pathology Neuropathology and Molecular Pathology, Medical University Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano 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