{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:01:12Z","timestamp":1786971672542,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","award":["K\u00fcchler\/Kirschneck accepted in July 4th, 2019"],"award-info":[{"award-number":["K\u00fcchler\/Kirschneck accepted in July 4th, 2019"]}],"id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/02704\u20101"],"award-info":[{"award-number":["2021\/02704\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Mandibular retrognathism (MR) is a skeletal malocclusion in which patients have a deficient mandibular length, resulting in a more posterior position of the mandible. We aimed to investigate the association between Single nucleotide polymorphisms (SNPs) in\n                      <jats:italic>Fibroblast Growth Factor Receptor 2<\/jats:italic>\n                      (\n                      <jats:italic>FGFR2)<\/jats:italic>\n                      gene and MR in germans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Genomic DNA and lateral cephalometric radiographs were obtained from orthodontic patients. Patients were allocated into the \u2018Retruded\u2019 group (SNB angle &lt;\u200978\u00b0) and into the \u2018Well\u2010positioned\u2019 group (SNB 78\u00b0\u201382\u00b0). The rs4752566, rs10736303, rs11200014, rs1078806, rs1219648, rs2981578 and rs2162540 SNPs were genotyped using real\u2010time PCR. Allele, genotype and haplotype frequencies were compared (\u03b1\u2009=\u20095%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 142 patients were included, 93 (65.5%) allocated into the \u2018Retruded\u2019 group and 49 (34.5%) into the \u2018Well\u2010positioned\u2019 group. The allele T in rs2981578 SNP was statistically more frequent in the \u2018Retruded\u2019 group in both univariate (PR\u2009=\u20091.22; 95% CI, =\u20091.02\u20131.47) and multivariate (PR\u2009=\u20091.55; 95% CI, =\u20091.07\u20132.25) analyses (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The CT\u2009+\u2009TT genotypes were statistically more frequent in the \u2018Retruded\u2019 group in univariate (PR\u2009=\u20091.58; 95% CI, =\u20091.03\u20132.41) and multivariate (PR\u2009=\u20091.59; 95% CI, =\u20091.11\u20132.26) analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). All studied SNPs were associated with MR establishment in haplotype analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      SNPs in the\n                      <jats:italic>FGFR2<\/jats:italic>\n                      are associated with MR and have the potential to serve as genetic biomarkers to early diagnosis and prediction of mandible growth.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ocr.70081","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T14:11:49Z","timestamp":1768227109000},"page":"538-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intronic Single Nucleotide Polymorphisms in\n                    <scp>FGFR2<\/scp>\n                    Gene Association With Non\u2010Syndromic Mandibular Retrognathism"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0606-1632","authenticated-orcid":false,"given":"Caio Luiz Bitencourt","family":"Reis","sequence":"first","affiliation":[{"name":"School of Dentistry Federal University of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kirschneck","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hemming","sequence":"additional","affiliation":[{"name":"School of Dentistry Tuiuti University of Paran\u00e1  Curitiba Parana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Paddenberg\u2010Schubert","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Proff","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Silva Barroso","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"School of Dentistry Federal University of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-4248","authenticated-orcid":false,"given":"Cristiano Miranda","family":"de Araujo","sequence":"additional","affiliation":[{"name":"School of Dentistry Tuiuti University of Paran\u00e1  Curitiba Parana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flares","family":"Baratto\u2010Filho","sequence":"additional","affiliation":[{"name":"School of Dentistry Tuiuti University of Paran\u00e1  Curitiba Parana Brazil"},{"name":"School of Dentistry University of the Joinville Region  Joinville Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8153-6610","authenticated-orcid":false,"given":"Svenja","family":"Beisel\u2010Memmert","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-2526","authenticated-orcid":false,"given":"Erika Calvano","family":"K\u00fcchler","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"issue":"6","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.14436\/2675-486X.19.6.113-125.art","article-title":"Tratamento da m\u00e1 oclus\u00e3o de Classe II com plano inclinado met\u00e1lico associado ao expansor h\u00edbrido apoiado em mini\u2010implantes","volume":"19","author":"Suzuki M. 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