{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:11:54Z","timestamp":1777972314116,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the expression of matrix metalloproteinase 9 and miRNA\u2010337\u20103p in oral squamous cell carcinoma tissues and analyse their clinical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Postoperative specimens from 30 oral squamous cell carcinoma (OSCC) patients were collected from June 2022 to January 2023, and real\u2010time fluorescence quantitative reverse transcription PCR was used to detect the expression levels of miR\u2010337\u20103p in cancer tissues and adjacent normal tissues. The correlation between the expression levels of the two and the clinicopathological parameters of patients was analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with adjacent normal tissues, the expression of miRNA\u2010337\u20103p in OSCC tissues was significantly lower (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and its expression level was clearly related to the lymph node metastasis status of OSCC patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The positive rates of MMP\u20109 in OSCC tissue and adjacent normal tissue were 83.33% and 36.67% respectively. Compared with patients in the N0 stage, the expression level of miRNA\u2010337\u20103p in OSCC tissues of patients in the N\n                      <jats:sub>1<\/jats:sub>\n                      \u2009+\u2009N\n                      <jats:sub>2<\/jats:sub>\n                      stage was significantly reduced (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The expression of MMP\u20109 and miRNA\u2010337\u20103p in OSCC tissues is related to cervical lymph node metastasis. miRNA\u2010337\u20103p plays a tumour suppressor role in OSCC and may inhibit OSCC cell invasion and metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ocr.70093","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:27:02Z","timestamp":1767166022000},"page":"553-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>miRNA<\/scp>\n                    \u2010337\u20103p and Matrix Metalloproteinase\u20109: Expression Patterns in Oral Squamous Cell Carcinoma and Prognostic Value for Cervical Lymph Node Metastasis"],"prefix":"10.1111","volume":"29","author":[{"given":"Hongyan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Stomatology Shaanxi Provincal People's Hospital  Xi'an Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shaanxi Provincal People's Hospital  Xi'an Shaanxi Province 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