{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:17:10Z","timestamp":1788517030346,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This review aimed to investigate platelet\u2010rich plasma (PRP) and platelet\u2010rich fibrin (PRF) efficiency in reducing oronasal fistula during primary cleft lip and palate repair. An extensive search of PubMed, Google Scholar, Global Index Medics (WHO), PubMed Scopus, Cochrane Central, Proquest was performed up to march 2025. Eligible studies included prospective RCTs and non\u2010randomized controlled trials in human subjects. Patients aged 6\u201324\u2009months undergoing primary cleft lip and palate repair were involved. Interventions involved intraoperative use of PRP\/PRF compared with controls without PRP\/PRF. The primary outcome was occurrence of oronasal fistula; secondary outcomes were scar width, wound infection and postoperative bleeding with wound dehiscence. Study selection followed PRISMA guidelines, and the risk of bias was determined with the ROB\u20102 and ROBINS\u2010I method of assessment. Seven studies met the required criterion and were qualitatively synthesized. Evidence suggested that PRP\/PRF application was associated with a lower incidence of oronasal fistula and reduced scar width compared with controls. Additional benefits included accelerated wound healing and faster recovery. The use of autologous PRP was also reported to decrease the need for further surgical interventions. However, the certainty of evidence was limited due to small sample sizes and methodological heterogeneity. PRP and PRF show promising benefits in cleft lip and palate repair, particularly decreased fistula formation and reduced scar width. Nevertheless, current evidence is of low to very low certainty. Larger, well\u2010designed randomized trials are required to validate the results obtained.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    PROSPERO registration no. CRD420251032421\n                  <\/jats:p>","DOI":"10.1111\/ocr.70147","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:29:02Z","timestamp":1779370142000},"page":"801-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Platelet Rich Plasma in Reducing Oronasal Fistula and Scar Width in Primary Cleft Lip and Palate Repair\u2014A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"29","author":[{"given":"Thiagasirpi","family":"Mani","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Chettinad Dental College and Hospital  Kelambakkam Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Munusamy","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Chettinad Dental College and Hospital  Kelambakkam Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-0543","authenticated-orcid":false,"given":"Prema","family":"Anbarasu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Chettinad Dental College and Hospital  Kelambakkam Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Harini","family":"Muruganandam","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Chettinad Dental College and Hospital  Kelambakkam Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Ponniah","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Chettinad Dental College and Hospital  Kelambakkam Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-3081","authenticated-orcid":false,"given":"Saravana Kumar","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Chettinad Dental College and Hospital  Kelambakkam Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"issue":"2","key":"e_1_2_13_2_1","first-page":"55","article-title":"Common Dental Anomalies in Cleft Lip and Palate Patients","volume":"22","author":"Haque S.","year":"2015","journal-title":"Malaysian Journal of Medical Sciences: MJMS"},{"key":"e_1_2_13_3_1","volume-title":"Craniofacial Growth and Development: Novel Insights","author":"Martinelli M.","year":"2021"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.57198"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1277714"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-925900"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.110096"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-3761"},{"key":"e_1_2_13_9_1","first-page":"55","article-title":"An Opportunity in Perio\u2010Implantology: The PRF","volume":"42","author":"Choukroun J.","year":"2001","journal-title":"Implantodontie"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2020.05.016"},{"key":"e_1_2_13_11_1","article-title":"Modified Platelet Rich Plasma (PRP) Technique in Repair of Primary Cleft Palate","volume":"106","author":"Yehya A.","year":"2020","journal-title":"Prensa M\u00e9dica Argentina"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2024.04.016"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665619884455"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25868"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.58675\/2682-339X.1632"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2024.10.005"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejhm.2019.63231"},{"key":"e_1_2_13_18_1","article-title":"Evaluation of the Role of Platelet\u2010Rich Fibrin (Prf) on Wound Healing Following Primary Cleft Palate Repair (a Pilot Study)","volume":"64","author":"Abushawaly H. A.","year":"2018","journal-title":"Dental Journal"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/392398"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_93_18"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.38931"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0746.83158"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-04981-5"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.17305\/bb.2024.10906"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjz165"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.04.015"}],"container-title":["Orthodontics &amp; Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.70147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ocr.70147","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.70147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:00:51Z","timestamp":1788516051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ocr.70147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/ocr.70147"],"URL":"https:\/\/doi.org\/10.1111\/ocr.70147","archive":["Portico"],"relation":{},"ISSN":["1601-6335","1601-6343"],"issn-type":[{"value":"1601-6335","type":"print"},{"value":"1601-6343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]},"assertion":[{"value":"2025-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}