{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:57:05Z","timestamp":1781243825750,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n To compare craniofacial morphology between individuals with isolated cleft lip (CL), cleft lip and palate (CLP), and a matched control group before and after the pubertal growth spurt.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n Cephalometric data from before and after the growth spurt were collected from 71 anonymized patients, of whom 29 (40.8%) had CLP, 13 (18.3%) had CL and 29 (40.8%) non\u2010cleft control patients presenting Angle Class I malocclusion. Data analysis included raw and standardized mean values along with comparisons using ANOVA and Kruskal\u2010Wallis tests. The significance level was set at 0.05.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n At baseline, mean ages were comparable across groups: 8.24\u2009\u00b1\u20090.94\u2009years (control), 8.24\u2009\u00b1\u20090.94\u2009years (CL), and 8.33\u2009\u00b1\u20092.44\u2009years (CLP). The cleft groups included a higher proportion of male individuals (CL: 76.9%, CLP: 62.1% vs. 48.3% for control), although not statistically significant. Patients with CL had significantly higher A\u2010Nasion\u2010B angle when compared with CLP and control groups. Individuals with CLP presented significantly lower values of Sella\u2010Nasion\u2010A and Sella\u2010Nasion\u2010B angles and significantly higher values of mandibular plane to Sella\u2010Nasion and gonial angles when compared to the control group. Changes in the maxillo\u2010mandibular relationship were observed in the CLP and CL groups, reaching Class III and Class I relationships after the growth spurt, respectively.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Although normal prepubertal maxillary prominence was observed in children with CL, impaired sagittal maxillary growth was recorded in this group during puberty. Individuals with CLP or CL present significant differences in maxillary and mandibular morphology and growth, which should be considered in orthodontic planning and treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ocr.70156","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:01:43Z","timestamp":1781240503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Craniofacial Growth in Patients With Cleft Before and After Puberty: A Longitudinal Case\u2013Control Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9127-5955","authenticated-orcid":false,"given":"M\u00f3nica Isabel Tavares","family":"Amorim","sequence":"first","affiliation":[{"name":"Division of Orthodontics, Faculdade de Medicina Dent\u00e1ria Universidade de Lisboa Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Godinho","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, Faculdade de Medicina Dent\u00e1ria Universidade de Lisboa Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Mario","family":"Caruso","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, Eastman Institute for Oral Health University of Rochester School of Medicine and Dentistry Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Arigo","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, Eastman Institute for Oral Health University of Rochester School of Medicine and Dentistry Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Jardim","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, Faculdade de Medicina Dent\u00e1ria Universidade de Lisboa Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Contemporary Orthodontics","author":"Proffit W.","year":"2003"},{"key":"e_1_2_12_3_1","first-page":"33","article-title":"Craniofacial Growth in Complete Unilateral Cleft Lip and Plate: A Roentgeno\u2010Cephalometric Study","volume":"34","author":"Hayashi I.","year":"1975","journal-title":"Japanese Orthodontic Society"},{"issue":"7","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0278-2391(92)90095-H","article-title":"Cranial Base Morphology in Cleft Lip and Palate: A Cephalometric Study From 7 to 18\u2009Years of Age","volume":"50","author":"Horswell B. 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