{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:03:36Z","timestamp":1792613016354,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate eruption pattern, in terms of space closure and alignment of second permanent molars (SPM), following extractions of first permanent molars (FPM) and assess the effect of predicting factors including age at extraction, developmental stage of SPM, angulation of adjacent teeth and presence of third permanent molars (TPM) on the outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective study included healthy children aged 6\u201312\u2009years who had undergone extraction of one or more severely compromised FMPs and had complete pre\u2010 and post\u2010extraction radiographic records until completion of the root formation of SPM and second premolar. Data on age, arch, extraction site, SPM developmental stage (Demirjian scale), angulation of adjacent teeth and presence of TPMs were collected from patients' records and pre\u2010extraction panoramic radiographs. Space closure and angulation of SPM were evaluated via post\u2010extraction radiographs. Descriptive statistics and logistic regression models were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty teeth, from 60 patients (mean age at extraction: 10.4\u2009years; mean follow\u2010up: 32\u2009months) were evaluated. Overall complete space closure was achieved in 75%, more prominent in the maxilla than the mandible (80% vs. 73%). Significantly higher closure rates were recorded in patients &lt;\u200910\u2009years at extraction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and when the SPM was at Demirjian developmental stages E\u2013F (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Upright angulation of SPM was observed in 78% of the cases, significantly more frequently in the maxilla (100%) than in the mandible (67%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Regression analysis identified the SPM developmental stage and the TPM presence as significant predictors of space closure, while the dental arch was the only significant predictor of upright SPM alignment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Spontaneous space closure and favourable alignment of the SPM occurred in most cases following extraction of compromised FPMs. The highest success rates were observed when extraction was performed between 8 and 10\u2009years of age and when the SPM was at Demirjian developmental stages E\u2013F, suggesting that these factors may represent the most reliable clinical indicators for optimal timing of extraction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ocr.70158","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T06:32:28Z","timestamp":1781505148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Eruption Pattern of Second Permanent Molars Following Extraction of Compromised First Permanent Molars in Children and Its Predicting Factors: A Retrospective Radiographic Study"],"prefix":"10.1111","author":[{"given":"Fanouria","family":"Papaioannou","sequence":"first","affiliation":[{"name":"School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4202-0566","authenticated-orcid":false,"given":"Konstantina","family":"Chatzidimitriou","sequence":"additional","affiliation":[{"name":"Department of Preventive &amp; Community Dentistry, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Seremidi","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heleni","family":"Vastardis","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotiria","family":"Gizani","sequence":"additional","affiliation":[{"name":"School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100528.2003.00016.x"},{"key":"e_1_2_12_3_1","first-page":"429","article-title":"Orthodontic Sequelae of Extraction of Permanent First Molars. A Longitudinal Study","volume":"46","author":"Thilander B.","year":"1970","journal-title":"Report of the Congress. European Orthodontic Society"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40510-022-00427-2"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/jispcd.JISPCD_222_17"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjae054"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14072221"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368\u2010013\u20100042\u20107"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2319\/061923\u2010423.1"},{"issue":"4","key":"e_1_2_12_10_1","first-page":"8","article-title":"The Timing of Extraction of Non\u2010Restorable First Permanent Molars: A Systematic Review Introduction","volume":"16","author":"Eichenberger M.","year":"2015","journal-title":"European Journal of Paediatric Dentistry"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368\u2010017\u20100283\u2010y"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2016.09.018"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjv029"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_606_20"},{"issue":"2","key":"e_1_2_12_15_1","first-page":"123","article-title":"Radiographic Evaluation of Permanent Second Molar Substitution After Extraction of Permanent First Molar: Identifying Predictors for Spontaneous Space Closure","volume":"44","author":"Nordeen K. A.","year":"2022","journal-title":"Pediatric Dentistry"},{"issue":"2","key":"e_1_2_12_16_1","first-page":"211","article-title":"A New System of Dental Age Assessment","volume":"45","author":"Demirjian A.","year":"1973","journal-title":"Human Biology"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.13273"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2014.1053"},{"key":"e_1_2_12_19_1","unstructured":"Royal College of Surgeons of England \u201cA Guideline for the Extraction of First Permanent Molars in Children \u201d(2014)."},{"key":"e_1_2_12_20_1","unstructured":"Royal College of Surgeons of England \u201cA Guideline for the Extraction of First Permanent Molars in Children \u201d(2023)."},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.18276"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031060"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13216596"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.7126\/cumudj.793013"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368-021-00647-w"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-018-0516-4"},{"key":"e_1_2_12_27_1","first-page":"252","article-title":"Radiographic Evaluation of Predictors for Spontaneous Space Closure and Supereruption After the Loss of Permanent First Molars in Yup'ik Children","volume":"45","author":"Lenaker D.","year":"2023","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_12_28_1","first-page":"349","article-title":"Early Loss of the First Molars 25\u2009Years After","volume":"46","author":"Thunold K.","year":"1970","journal-title":"Report of the Congress. European Orthodontic Society"}],"container-title":["Orthodontics &amp; Craniofacial Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.70158","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ocr.70158","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ocr.70158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T06:32:33Z","timestamp":1781505153000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ocr.70158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,14]]},"references-count":27,"alternative-id":["10.1111\/ocr.70158"],"URL":"https:\/\/doi.org\/10.1111\/ocr.70158","archive":["Portico"],"relation":{},"ISSN":["1601-6335","1601-6343"],"issn-type":[{"value":"1601-6335","type":"print"},{"value":"1601-6343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,14]]},"assertion":[{"value":"2026-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ocr.70158"}}