{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:59:46Z","timestamp":1785491986672,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthod Craniofacial Res"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether cleft type influences volumetric asymmetry of the maxillary sinus and nasal cavity using three\u2010dimensional computed tomography (CT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective study included 46 patients (24 unilateral cleft lip and palate [UCLP], 22 unilateral cleft lip and alveolus [UCLA]). Maxillary sinus and nasal cavity volumes were measured separately on the affected and non\u2010affected sides using CT. An asymmetry index (AI, %) was calculated as (affected \u2212 non\u2010affected)\/(affected + non\u2010affected)\u2009\u00d7\u2009100. Within\u2010group and between\u2010group comparisons were performed, and multiple linear regression analysis was used to determine whether cleft type independently predicted volumetric asymmetry after adjustment for age and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant side\u2010to\u2010side differences in both maxillary sinus and nasal cavity volumes were observed in the UCLP group (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas no significant asymmetry was detected in the UCLA group. The asymmetry index differed significantly between groups for both structures (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Cleft type independently predicted maxillary sinus asymmetry (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20098.11,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and nasal cavity asymmetry (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22126.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026). No significant correlation between sinus and nasal cavity asymmetry was found in UCLP, whereas a significant positive correlation was observed in UCLA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cleft type significantly influences volumetric asymmetry and the relationship between adjacent paranasal compartments. UCLP is associated with more pronounced asymmetry, whereas UCLA demonstrates more coordinated morphologic development. Cleft type\u2013specific three\u2010dimensional assessment should be considered in cleft care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ocr.70166","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:48:56Z","timestamp":1783921736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cleft Type Influences Volumetric Asymmetry of the Maxillary Sinus and Nasal Cavity: A CT Volumetric Study"],"prefix":"10.1111","author":[{"given":"Aoi","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Orthodontics Tokyo Dental College  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0654-1521","authenticated-orcid":false,"given":"Takenobu","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Tokyo Dental College  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Tokyo Dental College  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoka","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Tokyo Dental College  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Ariizumi","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Tokyo Dental College  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaho","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Tokyo Dental College  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Ishigaki","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Chiba Children's Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruo","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Tokyo Dental College Chiba Dental Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Nishii","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Tokyo Dental College  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.70041"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000009457"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665617726991"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.10.019"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/10556656221080359"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/10556656221149148"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/10556656211023239"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665618774024"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12739"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37326-8"},{"issue":"3","key":"e_1_2_13_12_1","article-title":"Three\u2010Dimensional Evaluation of Nasal Cavity Volume Using CBCT in CLP Patients","volume":"50","author":"Ling Y.","year":"2021","journal-title":"Dento Maxillo Facial Radiology"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.4274\/TurkJOrthod.2022.2022.4"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2014.59"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665619860700"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2016.03.031"}],"container-title":["Orthodontics &amp; 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