{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T06:01:00Z","timestamp":1770616860201,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T00:00:00Z","timestamp":1346976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study evaluated whether all the patients with serum gastric parietal cell antibody (<jats:styled-content style=\"fixed-case\">GPCA<\/jats:styled-content>) positivity had pernicious anemia (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The blood hemoglobin (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b), iron, and vitamin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 concentrations, and mean corpuscular volume (<jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content>) in 124 <jats:styled-content style=\"fixed-case\">GPCA<\/jats:styled-content>\u2010positive patients were measured and compared with the corresponding data in 124 age\u2010 and sex\u2010matched healthy controls. <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> was defined by World Health Organization (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>) as having an <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b concentration\u00a0&lt;\u00a013\u00a0g\u00a0dl<jats:sup>\u22121<\/jats:sup> for men and\u00a0&lt;\u00a012\u00a0g\u00a0dl<jats:sup>\u22121<\/jats:sup> for women, an MCV\u00a0\u2265\u00a0100\u00a0fl, and a serum vitamin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 level\u00a0&lt;\u00a0200\u00a0pg\u00a0ml<jats:sup>\u22121<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 20, 25, and 20 <jats:styled-content style=\"fixed-case\">GPCA<\/jats:styled-content>\u2010positive patients had deficiencies of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b (men\u00a0&lt;\u00a013\u00a0g\u00a0dl<jats:sup>\u22121<\/jats:sup>, women\u00a0&lt;\u00a012\u00a0g\u00a0dl<jats:sup>\u22121<\/jats:sup>), iron (&lt;60\u00a0\u03bcg\u00a0dl<jats:sup>\u22121<\/jats:sup>), and vitamin B12 (&lt;200\u00a0pg\u00a0ml<jats:sup>\u22121<\/jats:sup>), respectively. Moreover, 16 <jats:styled-content style=\"fixed-case\">GPCA<\/jats:styled-content>\u2010positive patients had abnormally high <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content> (\u2265100\u00a0fl). GPCA\u2010positive patients had a significantly higher frequency of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b, iron, or vitamin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 deficiency and of abnormally high <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content> (all <jats:italic>P\u2010<\/jats:italic>values\u00a0&lt;\u00a00.001) than healthy controls. However, only 12.9% of 124 <jats:styled-content style=\"fixed-case\">GPCA<\/jats:styled-content>\u2010positive patients were diagnosed as having <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> by the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> definition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Only 12.9% of GPCA\u2010positive patients are discovered to have PA by the WHO definition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12014","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T12:09:10Z","timestamp":1345205350000},"page":"381-386","source":"Crossref","is-referenced-by-count":75,"title":["Do all the patients with gastric parietal cell antibodies have pernicious anemia?"],"prefix":"10.1111","volume":"19","author":[{"given":"A","family":"Sun","sequence":"first","affiliation":[{"name":"School of Dentistry, National Taiwan University Taipei Taiwan"},{"name":"National Taiwan University Hospital, National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YP","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Dentistry, National Taiwan University Taipei Taiwan"},{"name":"National Taiwan University Hospital, National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Clinical Dentistry, National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HP","family":"Lin","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital, National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Clinical Dentistry, National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JS","family":"Chia","sequence":"additional","affiliation":[{"name":"School of Dentistry, National Taiwan University Taipei Taiwan"},{"name":"National Taiwan University Hospital, National Taiwan University Taipei Taiwan"},{"name":"Institute of Immunology, College of Medicine, National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Oral Biology, National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CP","family":"Chiang","sequence":"additional","affiliation":[{"name":"School of Dentistry, National Taiwan University Taipei Taiwan"},{"name":"National Taiwan University Hospital, National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Clinical Dentistry, National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Oral Biology, National Taiwan University Taipei 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