{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:15:08Z","timestamp":1777108508383,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T00:00:00Z","timestamp":1352246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2008\/05064-9"],"award-info":[{"award-number":["2008\/05064-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"name":"LABMULT\/UFRN\/RN"},{"name":"LABIOMOL\/UFRN\/RN"},{"name":"LABMAD\/USP\/SP"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate the contribution of 6 polymorphic variants of the <jats:italic><jats:styled-content style=\"fixed-case\">MSX<\/jats:styled-content>1<\/jats:italic> gene in non\u2010syndromic cleft lip and\/or palate (<jats:styled-content style=\"fixed-case\">NSCL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred and fifty\u2010eight individuals (158 <jats:styled-content style=\"fixed-case\">NSCL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content> cases and 200 controls) were genotyped by <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aq<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>an allelic discrimination using predesigned <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> assays. Statistical analyses were conducted using the software <jats:sc>spss<\/jats:sc> 15.0 and the <jats:sc>r<\/jats:sc> statistical suite. Haplotype block structure and haplotype frequencies were determined using the <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>aploview. A <jats:italic>P<\/jats:italic>\u2010value of 0.05 and confidence interval of 95% were used for all of statistical tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients with non\u2010syndromic cleft lip and\/or palate were characterized by similar distribution of <jats:italic><jats:styled-content style=\"fixed-case\">MSX<\/jats:styled-content>1<\/jats:italic> genotypes and allele in comparison to subjects without oral clefts (<jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05). Two haplotype blocks were constructed with polymorphisms of <jats:italic><jats:styled-content style=\"fixed-case\">MSX<\/jats:styled-content>1<\/jats:italic> gene and haplotypes formed showed a similar frequency in patients with and without oral clefts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study provides no evidence that <jats:italic><jats:styled-content style=\"fixed-case\">MSX<\/jats:styled-content>1<\/jats:italic> polymorphisms (rs3775261, rs1042484, rs12532, rs6446693, rs4464513 and rs1907998) play a major role in <jats:styled-content style=\"fixed-case\">NSCL<\/jats:styled-content>\/P.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12033","type":"journal-article","created":{"date-parts":[[2012,10,10]],"date-time":"2012-10-10T11:17:02Z","timestamp":1349867822000},"page":"507-512","source":"Crossref","is-referenced-by-count":20,"title":["<i><scp>MSX<\/scp>1<\/i> gene polymorphisms in non\u2010syndromic cleft lip and\/or palate"],"prefix":"10.1111","volume":"19","author":[{"given":"ML","family":"Cardoso","sequence":"first","affiliation":[{"name":"Department of Clinical and Toxicological Analysis School of Pharmaceutical Sciences Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JF","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis School of Pharmaceutical Sciences Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GHM","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis School of Pharmaceutical Sciences Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CD","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis School of Pharmaceutical Sciences Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SR","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Care Programme for Children with Cleft Lip and Palate Pediatrics Hospital Professor Heriberto Bezerra Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KSC","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis School of Pharmaceutical Sciences Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HPV","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis School of Pharmaceutical Sciences Federal University of Rio Grande do Norte Natal RN 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