{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:18:03Z","timestamp":1776835083780,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T00:00:00Z","timestamp":1352246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study evaluated whether supplementations of different vitamins and iron could reduce the serum homocysteine levels in 91 atrophic glossitis (<jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Atrophic glossitis (<jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>) patients with concomitant deficiencies of vitamin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 only (<jats:italic>n<\/jats:italic>\u00a0=\u00a039, group I), folic acid only (<jats:italic>n<\/jats:italic>\u00a0=\u00a010, group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>), iron only (<jats:italic>n<\/jats:italic>\u00a0=\u00a09, group <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>), or vitamin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 plus iron (<jats:italic>n<\/jats:italic>\u00a0=\u00a019, group <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) were treated with vitamin <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> capsules plus deficient hematinics. <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content> patients without definite hematinic deficiencies (<jats:italic>n<\/jats:italic>\u00a0=\u00a014, group <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>) were treated with vitamin <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> capsules only. The blood homocysteine and hematinic levels at baseline and after treatment till all oral symptoms had disappeared were measured and compared by paired <jats:italic>t<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Supplementations with vitamin <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> capsules plus corresponding deficient hematinics for groups <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> II<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> III<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IV<\/jats:styled-content> patients and with vitamin <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> capsules only for group <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> patients could reduce the high serum homocysteine levels to significantly lower levels after a mean treatment period of 8.3\u201311.6\u00a0months (all <jats:italic>P<\/jats:italic>\u2010values\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Supplementations with vitamin <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> capsules plus corresponding deficient hematinics or with vitamin <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> capsules only can reduce the high serum homocysteine levels to significantly lower levels in <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12035","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T21:38:16Z","timestamp":1350596296000},"page":"519-524","source":"Crossref","is-referenced-by-count":65,"title":["Significant reduction of homocysteine level with multiple <scp>B<\/scp> vitamins in atrophic glossitis patients"],"prefix":"10.1111","volume":"19","author":[{"given":"A","family":"Sun","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Dentistry National Taiwan University Taipei Taiwan"},{"name":"School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y\u2010P","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Dentistry National Taiwan University Taipei Taiwan"},{"name":"School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u2010P","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Dentistry National Taiwan University Taipei Taiwan"},{"name":"School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u2010M","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Oral Biology School of Dentistry National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u2010J","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u2010P","family":"Chiang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Dentistry National Taiwan University Taipei Taiwan"},{"name":"School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Oral Biology School of Dentistry National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S129"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/29.1.47"},{"key":"e_1_2_8_4_1","first-page":"335","article-title":"Incidence of tongue diseases based on epidemiologic studies (review of the literature)","volume":"85","author":"Dombi C","year":"1992","journal-title":"Fogorv Sz"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1976.tb01774.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300909.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197409122911101"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.53.6.731"},{"key":"e_1_2_8_9_1","first-page":"199","article-title":"Some local and systemic factors related to tongue inflammation","volume":"85","author":"J\u00e4rvinen J","year":"1989","journal-title":"Proc Finn Dent Soc"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2005.01.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90281-X"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060900"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.1.193"},{"key":"e_1_2_8_14_1","volume-title":"Preliminary Finding of the First Health and Nutrition Examination Survey, United States 1971\u20131972","author":"National Center for Health Statistics","year":"1975"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-3435-3.50008-7"},{"key":"e_1_2_8_16_1","first-page":"979","article-title":"Vitamin B12 deficiency","volume":"67","author":"Oh RC","year":"2003","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90149-X"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.6.3867"},{"key":"e_1_2_8_19_1","first-page":"2455","article-title":"Microcytic anemia","volume":"55","author":"Shine JW","year":"1997","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01122.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(97)00076-6"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00324.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2009.10718101"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804093381507"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12035","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T10:01:32Z","timestamp":1697277692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,7]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/odi.12035"],"URL":"https:\/\/doi.org\/10.1111\/odi.12035","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,7]]}}}