{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:07:03Z","timestamp":1792642023910,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Susceptibility to and severity of periodontal disease is influenced by gene polymorphisms related to the immune response. Co\u2010stimulatory molecules, such as <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>28 and <jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104, are critical in the development of such responses. Our hypothesis is that polymorphisms in genes that code for these molecules may be associated with periodontitis. The aim of the study was to investigate the association between +17 (T\/C) <jats:italic><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>28<\/jats:italic> and +49 (A\/G) <jats:italic><jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104<\/jats:italic> gene polymorphisms and periodontitis in Brazilians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Genomic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was obtained from oral swabs of 424 individuals categorized into three groups (control group, aggressive, and chronic periodontitis) considering clinical parameters such as probing depth and clinical attachment loss. The genotyping was performed by polymerase chain reaction\u2013restriction fragment length polymorphism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was an association between the T<jats:sup>\u2212<\/jats:sup> genotype of the <jats:italic><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>28<\/jats:italic> polymorphism and aggressive periodontitis (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04). Moreover, the A<jats:sup>+<\/jats:sup> genotype for <jats:italic><jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104<\/jats:italic> was associated with greater clinical attachment loss in non\u2010smokers with aggressive periodontitis (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.006, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a016.25, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a02.25\u2013117.11).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings show that T<jats:sup>\u2212<\/jats:sup> in <jats:italic><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>28\u00a0<\/jats:italic>+<jats:italic>\u00a0<\/jats:italic>17 (T\/C) and the A<jats:sup>+<\/jats:sup> in <jats:italic><jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104<\/jats:italic> +49 (A\/G) genotypes are associated with susceptibility to aggressive periodontal disease. Thus, our study highlights these polymorphisms as potential genetic susceptibility markers of periodontitis in Brazilians.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12036","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T21:38:15Z","timestamp":1350596295000},"page":"568-576","source":"Crossref","is-referenced-by-count":11,"title":["Association of <i><scp>CD<\/scp>28<\/i> and <i><scp>CTLA<\/scp>\u20104<\/i> gene polymorphisms with aggressive periodontitis in Brazilians"],"prefix":"10.1111","volume":"19","author":[{"given":"MRMA","family":"e Silva","sequence":"first","affiliation":[{"name":"Laboratory of Cell\u2010Cell Interactions Department of Morphology ICB Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PR","family":"Moreira","sequence":"additional","affiliation":[{"name":"Laboratory of Cell\u2010Cell Interactions Department of Morphology ICB Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GC","family":"da Costa","sequence":"additional","affiliation":[{"name":"Universidade Federal de Vi\u00e7osa Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AM","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Laboratory of Cell\u2010Cell Interactions Department of Morphology ICB Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PEA de","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Pathology Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SAF","family":"Amormino","sequence":"additional","affiliation":[{"name":"Laboratory of Cell\u2010Cell Interactions Department of Morphology ICB Universidade Federal de Minas Gerais Belo Horizonte 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