{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:08:54Z","timestamp":1785305334287,"version":"3.55.0"},"reference-count":78,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T00:00:00Z","timestamp":1356048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>Growth hormone (<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>) has significant effects on linear bone growth, bone mass and bone metabolism. The primary role of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> supplementation in children with <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> deficiency, those born small for gestational age or with other types of disorders in somatic development is to increase linear growth. However, <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> therapy seems to elicit varying responses in the craniofacial region. Whereas the effects of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> administration on somatic development are well documented, comparatively little is known of its effects on the craniofacial region. The purpose of this review was to search the literature and compile results from both animal and human studies related to the impact of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> on craniofacial growth.<\/jats:p>","DOI":"10.1111\/odi.12041","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T10:35:24Z","timestamp":1352284524000},"page":"559-567","source":"Crossref","is-referenced-by-count":12,"title":["Growth hormone therapy and craniofacial bones: a comprehensive review"],"prefix":"10.1111","volume":"19","author":[{"given":"G","family":"Litsas","sequence":"first","affiliation":[{"name":"Private Practise in Orthodontics Kozani Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0707"},{"key":"e_1_2_9_3_1","first-page":"1.1","volume-title":"Primer on the metabolic bone diseases and disorders of mineral metabolism","author":"Baron R","year":"2003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074507"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjm101"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330610312"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/19.2.131"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1190051"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-3-1402"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0509"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082872"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/235107a0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1179\/bjo.22.4.361"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.9.663"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2319\/011905-17"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.8.1408"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0036"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1538"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1985.tb00316.x"},{"key":"e_1_2_9_20_1","first-page":"50","article-title":"The effect of growth hormone on craniofacial growth and dental maturation in Turner syndrome","volume":"71","author":"Hass AD","year":"2001","journal-title":"Angle Orthod"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1630165"},{"key":"e_1_2_9_22_1","first-page":"44","article-title":"The correlation of facial growth with body height and skeletal maturation at adolescence","volume":"36","author":"Hunter CJ","year":"1966","journal-title":"Angle Orthod"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2003.07.013"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7079756"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-8-4-426"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(93)70017-I"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0301"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.03.002"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjm005"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2000.108005359.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(75)90208-0"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.19.1.437"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.10.7896"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1997.tb00216.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031033"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.135.4.7925111"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-121-3-1070"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-125-3-1239"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0096-6347(42)90605-7"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.22.4523"},{"key":"e_1_2_9_41_1","first-page":"109","article-title":"Effect of growth hormone on growth and development of the dentofacial complex in the young rat. A study by means of longitudinal roentgenographic cephalometrics","volume":"16","author":"Miura F","year":"1969","journal-title":"Bull Tokyo Med Dent Univ"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(55)90112-3"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2004.08.004"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.19.1.55"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330580305"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.2319\/102210-618.1"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016359509005969"},{"key":"e_1_2_9_48_1","first-page":"144","article-title":"Craniofacial features in patients with deficient and excessive growth hormone","volume":"14","author":"Pirinen S","year":"1994","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_9_49_1","first-page":"499","article-title":"The effect of growth hormone therapy on longitudinal growth of the oral facial structures in children","volume":"101","author":"Poole AE","year":"1982","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.02.004"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cji028"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/19.2.141"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591577506800226"},{"key":"e_1_2_9_54_1","first-page":"307","article-title":"Growth of the cartilages of the mid\u2010line cranial base: a radiographic and histological study","volume":"136","author":"Roberts GJ","year":"1983","journal-title":"J Anat"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1993.tb12698.x"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2001.115719"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(88)90379-9"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjp017"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1094075"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.12.037"},{"key":"e_1_2_9_61_1","first-page":"149","volume-title":"Oral and maxillofacial surgery","author":"Shum L","year":"2000"},{"key":"e_1_2_9_62_1","first-page":"169","article-title":"Further characterisation of the extracellular matrix in the mandibular condyle in neonatal mice","volume":"151","author":"Silbermman M","year":"1987","journal-title":"J Anat"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2005.02.016"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.05.003"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(71)90232-6"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10212"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj1954.33.655"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-595X(86)80005-6"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2007.10.054"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2006.05.040"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345970760091001"},{"key":"e_1_2_9_72_1","first-page":"184","article-title":"Craniofacial growth in short children born small for gestational age: two years follow\u2010up after high\u2010dose growth hormone treatment","volume":"17","author":"Van Erum R","year":"1997","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/20.4.417"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021172"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2003.12.007"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20051"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800100801"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2001.114536"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508401116"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12041","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:25:24Z","timestamp":1696519524000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,21]]},"references-count":78,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/odi.12041"],"URL":"https:\/\/doi.org\/10.1111\/odi.12041","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,21]]}}}