{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:17:09Z","timestamp":1791087429659,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T00:00:00Z","timestamp":1355270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The goal of this study was to investigate changes in nerve growth factor (<jats:styled-content style=\"fixed-case\">NGF<\/jats:styled-content>) and its high\u2010affinity receptor\u2010tropomyosin receptor kinase <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rk<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) expression in the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> after intra\u2010articular inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We employed the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ol1\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1\u03b2<jats:styled-content style=\"fixed-case\"><jats:sup>XAT<\/jats:sup><\/jats:styled-content> inducible model of joint inflammation. Changes in <jats:styled-content style=\"fixed-case\">NGF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rk<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> expression were evaluated by immunohistochemistry. The function of <jats:styled-content style=\"fixed-case\">NGF<\/jats:styled-content> on cell differentiation was assessed <jats:italic>in vitro<\/jats:italic> employing the <jats:styled-content style=\"fixed-case\">ATDC<\/jats:styled-content>5 chondrocyte cell line.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NGF<\/jats:styled-content> expression was observed in articular chondrocytes only after <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> inflammation, whereas TrkA expression was detected in articular chondrocytes under both na\u00efve as well as inflamed conditions. The potential effect of <jats:styled-content style=\"fixed-case\">NGF<\/jats:styled-content> on articular chondrocytes was studied on the <jats:styled-content style=\"fixed-case\">ATDC<\/jats:styled-content>5 cell line, whereby <jats:styled-content style=\"fixed-case\">NGF<\/jats:styled-content> decelerated the maturation rate of this chondrogenic cell line, presumably by arresting cell differentiation at the prehypertrophic stage of chondrocyte maturation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NGF<\/jats:styled-content>\u2010TrkA signaling in the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> provides potentially a means of protection against the development of osteoarthritis by decelerating chondrocyte differentiation. This discovery may lead to the development of novel therapies for osteoarthritis of the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> and other joints.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12045","type":"journal-article","created":{"date-parts":[[2012,11,24]],"date-time":"2012-11-24T11:15:01Z","timestamp":1353755701000},"page":"604-610","source":"Crossref","is-referenced-by-count":18,"title":["Nerve growth factor induced after temporomandibular joint inflammation decelerates chondrocyte differentiation"],"prefix":"10.1111","volume":"19","author":[{"given":"H","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Pediatric Dentistry School of Dental Medicine State University of New York at Stony Brook Stony Brook NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Shank","sequence":"additional","affiliation":[{"name":"School of Dental Medicine State University of New York at Stony Brook 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