{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:51:28Z","timestamp":1789570288955,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,12,25]],"date-time":"2012-12-25T00:00:00Z","timestamp":1356393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate how atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) contributes to root resorption during orthodontic tooth movement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Atopic dermatitis model mice and wild\u2010type mice were subjected to an excessive orthodontic force (<jats:styled-content style=\"fixed-case\">OF<\/jats:styled-content>) to induce movement of the upper first molars. The expression levels of the tartrate\u2010resistant acid phosphatase (<jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, and <jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content> proteins were determined in the periodontal ligament (<jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content>) by an immunohistochemical analysis. Furthermore, the effects of the compression force on co\u2010cultures of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> cells from <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients or healthy individuals and human <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content> cells were investigated with regard to the levels of secretion and m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content>, and osteoprotegerin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The immunoreactivities for <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u201017, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, and <jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> group were found to be significantly increased. The double immunofluorescence analysis for <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 detected immunoreaction. The secretion of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, and <jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content>, and the m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients were increased compared with those in healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Th17 cells may therefore be associated with the deterioration of root resorption of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> mice, and may explain why <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients are more susceptible to root resorption than healthy individuals when an excessive <jats:styled-content style=\"fixed-case\">OF<\/jats:styled-content> is applied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12053","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T18:58:56Z","timestamp":1354647536000},"page":"683-693","source":"Crossref","is-referenced-by-count":15,"title":["Th17\u2010cells in atopic dermatitis stimulate orthodontic root resorption"],"prefix":"10.1111","volume":"19","author":[{"given":"K","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Orthodontics Nihon University School of Dentistry at Matsudo Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Nihon University School of Dentistry at Matsudo Chiba 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