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The aim of this study is to introduce a new three\u2010dimensional (3D) analysis of clinical value for evaluating asymmetry in cases of craniofacial syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>Virtual 3D models were reconstructed from <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> images of 62 normal subjects (35 males and 27 females), more than 18\u00a0years old. Measurements of asymmetrical skeletal and dentoalveolar relationships were evaluated and standardized data obtained. The feasibility of the new 3D craniofacial analysis was then evaluated on one patient with severe maxillomandibular asymmetry in the form of hemifacial microsomia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Standardized 3D data from the analysis were obtained and classified into 6 maxillary measurements, eight mandibular measurements and seven dentoalveolar process measurements. No significant differences were found between males and females (<jats:italic>U<\/jats:italic>\u2010Mann\u2013Whitney test, <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Useful data of clinical value was provided for planning orthodontic and surgical treatment of asymmetries, as well as a diagnostic chart.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This method is useful for the clinical evaluation of asymmetry in craniofacial syndromes. The use of 3D analysis facilitates surgical and orthodontic treatment planning.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12059","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T16:01:56Z","timestamp":1355241716000},"page":"755-762","source":"Crossref","is-referenced-by-count":14,"title":["A new three\u2010dimensional analysis of asymmetry for patients with craniofacial syndromes"],"prefix":"10.1111","volume":"19","author":[{"given":"R\u2010M","family":"Y\u00e1\u00f1ez\u2010Vico","sequence":"first","affiliation":[{"name":"Department of Stomatology School of Dentistry University of Seville Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Iglesias\u2010Linares","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of Seville Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Torres\u2010Lagares","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of Seville Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u2010L","family":"Guti\u00e9rrez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of Seville Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Solano\u2010Reina","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of Seville Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/8.3.141"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199309001-00003"},{"key":"e_1_2_10_4_1","first-page":"45","article-title":"A new x\u2010ray technique and its application to orthodontia","volume":"1","author":"Broadbent B","year":"1931","journal-title":"Angle Orthod"},{"key":"e_1_2_10_5_1","first-page":"676","article-title":"Three\u2010dimensional computed tomography imaging in the evaluation of craniofacial abnormalities","volume":"86","author":"Darling CF","year":"1994","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199605000-00006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(83)90322-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/8.3.149"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4041\/kjod.2012.42.2.56"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/23.5.569"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2003.01.004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(2000)037<0349:SODCMF>2.3.CO;2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2005.07.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2005.11.031"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2012.03.024"},{"key":"e_1_2_10_16_1","first-page":"61","article-title":"Three\u2010dimensional surface imaging from CT scans for the study of craniofacial dysmorphology","volume":"9","author":"Marsh JL","year":"1989","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(1997)034<0036:TDATPT>2.3.CO;2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(1997)034<0052:TDATPC>2.3.CO;2"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31819b96a5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(79)90093-9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2007.05.022"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2005.11.032"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2319\/102911-668.1"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199307000-00002"},{"key":"e_1_2_10_25_1","unstructured":"SEDENTEXCT(2011).Evidence Based Guidelines of SEDENTEXCT for dental and maxillofacial radiology. 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