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Potential teratogenicity of antiepileptic drugs (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s) is of concern to these women considering pregnancy because discontinuing pharmacotherapy during pregnancy may not be advised due to the risk of seizures that may be dangerous to the mother as well as the fetus. Using a Relational Online Analytical Processing (<jats:styled-content style=\"fixed-case\">ROLAP<\/jats:styled-content>) software licensed by Simultek, we searched for medications reported for congenital jaw and oral cavity malformation on the <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content> Adverse Event Reporting System (<jats:styled-content style=\"fixed-case\">AERS<\/jats:styled-content>), a voluntary adverse event reporting program that contains over 55 million adverse event reports of medical products in the United.States. Our results indicate that various forms of valproic acid, and more importantly, newer generation antiepileptic agents including lamotrigine, topiramate, and gabapentin show signals for either congenital jaw or oral malformation. Although teratogenic potential of valproic acid has long been confirmed, information on teratogenicity of the newer generation antiepileptic drugs is relatively scarce and inconclusive. Early safety signals on the teratogenic potential of <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s detected in this study are crude statistics that do not establish causation nor exclude confounding. The results require validation and further investigation via properly controlled epidemiological studies.<\/jats:p>","DOI":"10.1111\/odi.12061","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T13:01:43Z","timestamp":1356613303000},"page":"712-720","source":"Crossref","is-referenced-by-count":17,"title":["Antiepileptic drugs (<scp>AED<\/scp>s) during pregnancy and risk of congenital jaw and oral malformation"],"prefix":"10.1111","volume":"19","author":[{"given":"J","family":"Koo","sequence":"first","affiliation":[{"name":"Columbia University College of Dental Medicine New York New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Zavras","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and of Dentistry Division of Oral Epidemiology &amp; Biostatistics Dental Public Health Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 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