{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:27:13Z","timestamp":1769635633655,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T00:00:00Z","timestamp":1359331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to compare the expression of proteins p53,<jats:styled-content style=\"fixed-case\">MDM<\/jats:styled-content>2, and<jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content>\u20101 in oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) lesions, epithelial dysplasia, and squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The sample consisted of the following five groups of cheek mucosa lesions: normal mucosa (<jats:styled-content style=\"fixed-case\">NM<\/jats:styled-content>), inflammatory fibrous hyperplasia (<jats:styled-content style=\"fixed-case\">IFH<\/jats:styled-content>), lichen planus, epithelial dysplasia, and squamous cell carcinoma. The tissue samples were stained with hematoxylin\u2010eosin and submitted to immunohistochemistry using anti\u2010p53, anti\u2010<jats:styled-content style=\"fixed-case\">MDM<\/jats:styled-content>2, and anti\u2010<jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content>\u20101 antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of this study demonstrated similar expression of p53 and<jats:styled-content style=\"fixed-case\">MDM<\/jats:styled-content>2 between<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>, oral epithelial dysplasia and, to a lesser extent, between<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>and oral squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>). However, for<jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content>\u20101 a similar expression was observed in<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">NM<\/jats:styled-content>, and<jats:styled-content style=\"fixed-case\">IFH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results demonstrated overexpression of important proteins (p53 and<jats:styled-content style=\"fixed-case\">MDM<\/jats:styled-content>2) related to regulatory mechanisms of apoptosis in<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>, suggesting that there is a favorable environment for malignant transformation. The expression of<jats:styled-content style=\"fixed-case\">SUMO<\/jats:styled-content>\u20101 in<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>was similar to<jats:styled-content style=\"fixed-case\">NM<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">IFH<\/jats:styled-content>, suggesting that alterations of this protein occur at later stages of carcinogenesis, because important overexpression occurred in oral epithelial dysplasia and<jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12068","type":"journal-article","created":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T16:47:50Z","timestamp":1357922870000},"page":"775-780","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of the expression of p53,<scp>MDM<\/scp>2, and<scp>SUMO<\/scp>\u20101 in oral lichen planus"],"prefix":"10.1111","volume":"19","author":[{"given":"MG","family":"Oliveira Alves","sequence":"first","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis S\u00e3o Jos\u00e9 dos Campos Dental School UNESP \u2013 Univ Estadual Paulista S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Balducci","sequence":"additional","affiliation":[{"name":"Department of Social Science and Pediatric Dentisty S\u00e3o Jos\u00e9 dos Campos Dental School UNESP \u2013 Univ Estadual Paulista S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Rodarte Carvalho","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis S\u00e3o Jos\u00e9 dos Campos Dental School UNESP \u2013 Univ Estadual Paulista S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAG","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis S\u00e3o Jos\u00e9 dos Campos Dental School UNESP \u2013 Univ Estadual Paulista S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FD","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JD","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis S\u00e3o Jos\u00e9 dos Campos Dental School UNESP \u2013 Univ Estadual Paulista S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,28]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"66","article-title":"Oral lichen planus. 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